LAMP2

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also function in the protection, maintenance, and adhesion of the lysosome. Alternative splicing of this gene results in multiple transcript variants encoding distinct proteins.

LAMP2

Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125, PubMed:27628032).
Functions by binding target proteins, such as GAPDH and MLLT11, and targeting them for lysosomal degradation (PubMed:8662539, PubMed:11082038, PubMed:18644871, PubMed:24880125).
Plays a role in lysosomal protein degradation in response to starvation (By similarity).
Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032).
Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032).
Required for normal degradation of the contents of autophagosomes (PubMed:27628032).
Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits (PubMed:20518820).
Is not required for efficient MHCII-mediated presentation of endogenous antigens (PubMed:20518820).
Isoform LAMP-2C
Modulates chaperone-mediated autophagy. Decreases presentation of endogenous antigens by MHCII. Does not play a role in the presentation of exogenous and membrane-derived antigens by MHCII.
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.

Autophagosome maturationISS:UniProtKB
Cellular response to starvationISS:UniProtKB
Chaperone-mediated autophagyManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL
Establishment of protein localization to organelleManual Assertion Based On ExperimentIBA:GO_Central
Lysosomal protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Muscle cell cellular homeostasisIEA:Ensembl
Negative regulation of protein-containing complex assemblyIDA:ParkinsonsUK-UCL
Protein importManual Assertion Based On ExperimentTAS:ParkinsonsUK-UCL
Protein stabilizationISS:CAFA
Protein targetingISS:UniProtKB
Protein targeting to lysosome involved in chaperone-mediated autophagyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of protein stabilityManual Assertion Based On ExperimentIMP:ParkinsonsUK-UCL

Cell membrane
Endosome membrane
Lysosome membrane
Cytoplasmic vesicle, autophagosome membrane
This protein shuttles between lysosomes, endosomes, and the plasma membrane.

Danon disease (DAND):
DAND is a lysosomal glycogen storage disease characterized by the clinical triad of cardiomyopathy, vacuolar myopathy and mental retardation. It is often associated with an accumulation of glycogen in muscle and lysosomes.

Lumenal: 29-375
Helical: 376-399
Cytoplasmic: 400-410

O- and N-glycosylated; some of the 16 N-linked glycans are polylactosaminoglycans.