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LAMP1

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis.

Full Name

LAMP1

Function

Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, autophagy, and cholesterol homeostasis (By similarity).
Plays also an important role in NK-cells cytotoxicity (PubMed:23632890, PubMed:2022921).
Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (PubMed:23632890).
In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195).
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.
(Microbial infection) Acts as a receptor for Lassa virus glycoprotein (PubMed:24970085).
Promotes also fusion of the virus with host membrane in less acidic endosomes (PubMed:29295909).
(Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.

Biological Process

Establishment of protein localization to organelleManual Assertion Based On ExperimentIMP:UniProtKB
Golgi to lysosome transportManual Assertion Based On ExperimentIMP:UniProtKB
Granzyme-mediated programmed cell death signaling pathwayManual Assertion Based On ExperimentIMP:GO_Central
Positive regulation of natural killer cell degranulationManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:UniProtKB
Protein stabilizationISS:CAFA
Regulation of organelle transport along microtubuleManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell membrane
Endosome membrane
Lysosome membrane
Late endosome membrane
Cytolytic granule membrane
This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity).
Colocalizes with OSBPL1A at the late endosome (PubMed:16176980).

Topology

Lumenal: 29-382
Helical: 383-405
Cytoplasmic: 406-417

PTM

O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans. The glycosylation of N-76 is essential for Lassa virus entry into cells.

Anti-LAMP1 antibodies

Rat Anti-LAMP1 Recombinant Antibody (CBWJC-4114) (CBMAB-C5457WJ)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBWJC-4114

Application*: B, IF

Mouse Anti-LAMP1 Recombinant Antibody (CBWJC-4111) (CBMAB-C5454WJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4111

Application*: E

Mouse Anti-LAMP1 Recombinant Antibody (B-K9) (CBMAB-C5453WJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: B-K9

Application*: IC, F

Mouse Anti-LAMP1 Monoclonal Antibody (B-T47) (CBMAB-1375-YC)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-T47

Application*: F

Mouse Anti-LAMP1 Monoclonal Antibody (LY1C6) (CBMAB-1374-YC)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat, Mouse, Hamster

Clone: LY1C6

Application*: IP, IC, IF, WB

Rat Anti-LAMP1 Recombinant Antibody (1D4B) (CBMAB-0073-CN)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 1D4B

Application*: E, IF, IH, IP, WB

Mouse Anti-LAMP1 Antibody (H4A3) (CBMAB-1384CQ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Hamster, Rat

Clone: H4A3

Application*: IF, IH, WB

Mouse Anti-LAMP1 Antibody (G1/139/5) (CBMAB-1383CQ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: G1/139/5

Application*: IF, IP, WB

Mouse Anti-LAMP1 Recombinant Antibody (CBWJC-4110) (CBMAB-C5452WJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBWJC-4110

Application*: F

Mouse Anti-LAMP1 Recombinant Antibody (CBWJC-2319) (CBMAB-C3227WJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Rat

Clone: CBWJC-2319

Application*: F, C, IP, WB

Mouse Anti-LAMP1 Recombinant Antibody (CBWJC-2318) (CBMAB-C3226WJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJC-2318

Application*: F, IC, IF, P, WB

Rat Anti-LAMP1 Recombinant Antibody (CBWJC-2317) (CBMAB-C3225WJ)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBWJC-2317

Application*: F, C, P, IP, WB

Mouse Anti-LAMP1 Recombinant Antibody (B-N8) (CBMAB-C3223WJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: B-N8

Application*: E, F, FN, IH

Mouse Anti-LAMP1 Recombinant Antibody (CBXC-1865) (CBMAB-C3336-CQ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-1865

Application*: F

Rat Anti-LAMP1 Recombinant Antibody (CBFYC-0386) (CBMAB-C0427-FY)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBFYC-0386

Application*: F

Rat Anti-Lamp1 Recombinant Antibody (CBYJL-2523) (CBMAB-L2929-YJ)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBYJL-2523

Application*: F, C, P, IP, WB

Rat Anti-Lamp1 Recombinant Antibody (CBYJL-2522) (CBMAB-L2928-YJ)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYJL-2522

Application*: IC

Rat Anti-Lamp1 Recombinant Antibody (CBYJL-2521) (CBMAB-L2927-YJ)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBYJL-2521

Application*: IC

Rat Anti-Lamp1 Recombinant Antibody (CBYJL-2520) (CBMAB-L2926-YJ)

SDS

Target: LAMP1

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: CBYJL-2520

Application*: F, IH, IP, WB

Rabbit Anti-LAMP1 Recombinant Antibody (CBYJL-1159) (CBMAB-L0650-YJ)

SDS

Target: LAMP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1159

Application*: F

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1158) (CBMAB-L0649-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1158

Application*: WB, IP, IF

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1157) (CBMAB-L0648-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG3

Specificity: Human

Clone: CBYJL-1157

Application*: WB, P

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1156) (CBMAB-L0647-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1156

Application*: F

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1155) (CBMAB-L0646-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBYJL-1155

Application*: WB, P

Rabbit Anti-LAMP1 Recombinant Antibody (CBYJL-1153) (CBMAB-L0642-YJ)

SDS

Target: LAMP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Monkey

Clone: CBYJL-1153

Application*: WB, IP, P, IF

Rabbit Anti-LAMP1 Recombinant Antibody (CBYJL-1152) (CBMAB-L0641-YJ)

SDS

Target: LAMP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey

Clone: CBYJL-1152

Application*: WB

Mouse Anti-LAMP1 Recombinant Antibody (9H151) (CBMAB-L0636-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 9H151

Application*: F

Mouse Anti-LAMP1 Recombinant Antibody (9A179) (CBMAB-L0635-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9A179

Application*: F

Mouse Anti-LAMP1 Recombinant Antibody (6E2) (CBMAB-L0634-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Pig, Cattle

Clone: 6E2

Application*: WB, IC, IF

Mouse Anti-LAMP1 Recombinant Antibody (5K76) (CBMAB-L0633-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5K76

Application*: F, IH

Mouse Anti-LAMP1 Recombinant Antibody (5H6) (CBMAB-L0632-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat, Pig, Cattle

Clone: 5H6

Application*: WB, IC, IF

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1150) (CBMAB-L0631-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYJL-1150

Application*: WB, IH, IC, IF, P

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1149) (CBMAB-L0630-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1149

Application*: F

Mouse Anti-LAMP1 Recombinant Antibody (4E151) (CBMAB-L0629-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Hamster, Rat

Clone: 4E151

Application*: IC, IF, IP, WB

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1147) (CBMAB-L0627-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1147

Application*: WB, IP

Mouse Anti-LAMP1 Recombinant Antibody (1483CT517.45.23) (CBMAB-L0626-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1483CT517.45.23

Application*: E, WB

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1145) (CBMAB-L0624-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Cattle, Mouse, Pig, Rat

Clone: CBYJL-1145

Application*: IF, WB

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1144) (CBMAB-L0623-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBYJL-1144

Application*: F, IC, WB

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1143) (CBMAB-L0622-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1143

Application*: WB

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1142) (CBMAB-L0621-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJL-1142

Application*: N

Rabbit Anti-LAMP1 Recombinant Antibody (CBYJL-1141) (CBMAB-L0620-YJ)

SDS

Target: LAMP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1141

Application*: F

Mouse Anti-LAMP1 Recombinant Antibody (CBYJL-1140) (CBMAB-L0619-YJ)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJL-1140

Application*: EC

Mouse Anti-LAMP1 Recombinant Antibody (A860) (CBMAB-AP11312LY)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Hamster, Human, Mouse, Rat

Clone: A860

Application*: ICC/IF, IP, WB

Rabbit Anti-LAMP1 Recombinant Antibody (C54H11) (CBMAB-CP1344-LY)

SDS

Target: LAMP1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Monkey

Clone: C54H11

Application*: WB

Mouse Anti-LAMP1 Recombinant Antibody (CBYY-C2633) (CBMAB-C4074-YY)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Cattle, Human, Mouse, Rat

Clone: CBYY-C2633

Application*: IF, WB

Mouse Anti-LAMP1 Recombinant Antibody (4E9/11) (CBMAB-C0899-YY)

SDS

Target: LAMP1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Pig

Clone: 4E9/11

Application*: C, F, IP, P, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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