LACC1

This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages.

LACCASE DOMAIN CONTAINING 1

Purine nucleoside enzyme that catalyzes the phosphorolysis of adenosine, guanosine and inosine nucleosides, yielding D-ribose 1-phosphate and the respective free bases, adenine, guanine and hypoxanthine (PubMed:31978345).
Also catalyzes the phosphorolysis of S-methyl-5'-thioadenosine into adenine and S-methyl-5-thio-alpha-D-ribose 1-phosphate (PubMed:31978345).
Also has adenosine deaminase activity (PubMed:31978345).
Acts as a regulator of innate immunity in macrophages by modulating the purine nucleotide metabolism, thereby regulating the metabolic function and bioenergetic state of macrophages (PubMed:31978345).
Enables a purine nucleotide cycle between adenosine and inosine monophosphate and adenylosuccinate that prevents cytoplasmic acidification and balances the cytoplasmic-mitochondrial redox interface (PubMed:31978345).
The purine nucleotide cycle consumes aspartate and releases fumarate in a manner involving fatty acid oxidation and ATP-citrate lyase activity (PubMed:31978345).
Participates in pattern recognition receptor (PRR)-induced cytokines in macrophages: associates with the NOD2-signaling complex and promotes optimal NOD2-induced signaling, cytokine secretion and bacterial clearance (PubMed:28593945, PubMed:31875558).
Localizes to the endoplasmic reticulum upon PRR stimulation of macrophages and associates with endoplasmic reticulum-stress sensors, promoting the endoplasmic reticulum unfolded protein response (UPR) (PubMed:31875558).
Does not show laccase activity (PubMed:27959965, PubMed:31978345).

Inflammatory responseIEA:UniProtKB-KW
Innate immune responseIEA:UniProtKB-KW
Nucleotide-binding oligomerization domain containing 2 signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Pattern recognition receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of cytokine production involved in immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cellular pHManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of inflammatory responseISS:UniProtKB
Regulation of purine nucleotide metabolic processISS:UniProtKB

Cytoplasm
Nucleus
Endoplasmic reticulum
Peroxisome
Upon stimulation of the pattern-recognition receptor (PRR) NOD2, localizes to the endoplasmic reticulum.

Juvenile arthritis (JUVAR):
A rare, familial form of juvenile arthritis characterized by autosomal recessive inheritance and onset in early childhood of symmetric, chronic joint inflammation. It causes joint swelling, pain, stiffness and restricted joint movement. JUVAR has high clinical variability. Some patients exhibit systemic symptoms, including quotidian fever, erythematous rash, generalized lymphadenopathy, hepatomegaly, and/or splenomegaly. Others display polyarthritis without systemic inflammation.

Phosphorylated on tyrosine residues.