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KRT5

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Full Name
Keratin 5
Biological Process
Epidermis developmentManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Cytosol
Extracellular exosome
Intermediate filament
Keratin filament
Membrane
Nucleus
Involvement in disease
Epidermolysis bullosa simplex, autosomal recessive 1 (EBSB1):
A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering and cleavage within basal keratinocytes, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma.
Epidermolysis bullosa simplex, Dowling-Meara type (DM-EBS):
A severe form of intraepidermal epidermolysis bullosa characterized by generalized herpetiform blistering, milia formation, dystrophic nails, and mucous membrane involvement.
Epidermolysis bullosa simplex, with migratory circinate erythema (EBSMCE):
A form of intraepidermal epidermolysis bullosa characterized by unusual migratory circinate erythema. Skin lesions appear from birth primarily on the hands, feet, and legs but spare nails, ocular epithelia and mucosae. Lesions heal with brown pigmentation but no scarring. Electron microscopy findings are distinct from those seen in the DM-EBS, with no evidence of tonofilament clumping.
Epidermolysis bullosa simplex, Weber-Cockayne type (WC-EBS):
A form of intraepidermal epidermolysis bullosa characterized by blistering limited to palmar and plantar areas of the skin.
Epidermolysis bullosa simplex, Koebner type (K-EBS):
A form of intraepidermal epidermolysis bullosa characterized by generalized skin blistering. The phenotype is not fundamentally distinct from the Dowling-Meara type, although it is less severe.
Epidermolysis bullosa simplex, with mottled pigmentation (MP-EBS):
A form of intraepidermal epidermolysis bullosa characterized by blistering at acral sites and 'mottled' pigmentation of the trunk and proximal extremities with hyper- and hypopigmentation macules.
Dowling-Degos disease 1 (DDD1):
An autosomal dominant genodermatosis. Affected individuals develop a postpubertal reticulate hyperpigmentation that is progressive and disfiguring, and small hyperkeratotic dark brown papules that affect mainly the flexures and great skin folds. Patients usually show no abnormalities of the hair or nails.

Anti-KRT5 antibodies

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Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Cattle, Dog, Pig, Sheep, Hamster, Ferret
Clone: SPM268
Application*: WB, P, IF/IC, F
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP27
Application*: P
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: SP178
Application*: P, F
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM226
Application*: IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RCK103
Application*: C, P
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D5/16B4
Application*: IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 34946;E12
Application*: P, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 16.4
Application*: C, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B209
Application*: E, C, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Chicken, Rat, Frog
Clone: 10B2635
Application*: IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4H8
Application*: P
Target: KRT5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: 3D6D4
Application*: WB, F, E, IH, IF, IC, MC
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C8E4
Application*: WB, F, E, IH, IF, IC, MC
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4A7
Application*: IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 12C4
Application*: WB, F, E, IC/IF
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat, Cattle, Dog, Pig, Sheep, Hamster, Ferret
Clone: CBLY1-154
Application*: WB, P, IF/IC, F
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: XM26
Application*: IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10C11E6
Application*: E, P, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: V2-53153
Application*: E, F, IC, IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1F8
Application*: P
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1E7
Application*: P
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E6
Application*: WB
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EP1601Y
Application*: C, IC/IF, WB, P
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D4U8Q
Application*: WB, IF, F
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey, Rabbit, Mouse, Rat, Cattle, Chicken
Clone: AE3
Application*: IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H8
Application*: E, IF, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1C7
Application*: P, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F8
Application*: IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1A12
Application*: E, IP, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: V2-53157
Application*: WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 14i119
Application*: E, IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3E2F1
Application*: E, WB, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B214
Application*: E, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C2B4
Application*: E
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4058
Application*: IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1-00E-01
Application*: E, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4057
Application*: E, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1-00E-001
Application*: WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A8
Application*: E, WB, IC, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-4065
Application*: IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E1
Application*: WB, IH, E
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4061
Application*: IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2894
Application*: E, WB, P, IF, F
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBFYC-2895
Application*: E, F, IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C11
Application*: E, WB, IC, IH
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 176
Application*: WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 16-04-14
Application*: C, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4059
Application*: P
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B216
Application*: E, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B181
Application*: E, F, IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Amphibia, Cattle, Human, Mouse, Pig
Clone: Ks5+8.22/C22
Application*: F, P, E
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LP34
Application*: C
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: n.a
Application*: E, P, WB
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2295
Application*: WB, IP, P, C, IC
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Human
Clone: CBWJC-2294
Application*: WB, P, C, IC
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cattle, Frog, Human, Mouse, Pig
Clone: CBFYC-2897
Application*: E, F, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, IgG2a
Specificity: Human, Rat
Clone: CBFYC-2898
Application*: IF, IH, IP, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2899
Application*: WB, F, E, IF
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2730
Application*: WB, F, E, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: CBXC-2843
Application*: WB, F, E, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat, Pig, Dog, Ferret, Hamster, Sheep
Clone: C-50
Application*: WB, F, P, IF
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1943
Application*: WB, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-1988
Application*: WB, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2346
Application*: WB, E, IH
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Cattle, Ferret, Human, Rat, Frog
Clone: 8J1145
Application*: IC, IF, C, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BS42
Application*: P
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: T16-K
Application*: P
Target: KRT5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: RM341
Application*: IHC, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 6A1
Application*: IHC
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Amphibian, Cattle, Mouse, Pig
Clone: C22
Application*: F, IF, C, P
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Dog, Cat, Hamster, Rabbit
Clone: RCK102
Application*: WB, F, IF, P, C
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Monkey
Clone: CBYY-C3139
Application*: E, WB, P, IF, F
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AT12C4
Application*: E, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBCNC-642
Application*: WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2613
Application*: IC, IF, IH, WB
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CB121A
Application*: ELISA, IHC
Target: KRT5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: A831
Application*: ICC, IHC, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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