KDM5B

This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants.

lysine demethylase 5B

Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558).
Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722).
In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity).

Branching involved in mammary gland duct morphogenesisIEA:Ensembl
Cellular response to fibroblast growth factor stimulusIEA:Ensembl
Cellular response to leukemia inhibitory factorIEA:Ensembl
Chromatin remodelingManual Assertion Based On ExperimentIBA:GO_Central
Histone H3-K4 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Lens fiber cell differentiationIEA:Ensembl
Mammary duct terminal end bud growthIEA:Ensembl
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:GDB
Positive regulation of gene expressionIEA:Ensembl
Positive regulation of mammary gland epithelial cell proliferationIEA:Ensembl
Post-embryonic developmentIEA:Ensembl
Regulation of estradiol secretionIEA:Ensembl
Response to fungicideIEA:Ensembl
Rhythmic processIEA:UniProtKB-KW
Single fertilizationIEA:Ensembl
Uterus morphogenesisIEA:Ensembl

Nucleus

Mental retardation, autosomal recessive 65 (MRT65):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT65 patients have moderate to severe intellectual disability, developmental delay, and facial dysmorphism. Camptodactyly is present in some patients.