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ITGAL

ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene.
Full Name
Integrin Subunit Alpha L
Alternative Names
Integrin Subunit Alpha L
Function
Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364).
Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055).
Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110).
Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992).
Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity).
Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Biological Process
Cell adhesion1 PublicationNAS:UniProtKB
Cell-cell adhesionBy SimilarityISS:BHF-UCL
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesManual Assertion Based On ExperimentIMP:BHF-UCL
Inflammatory response1 PublicationNAS:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Leukocyte cell-cell adhesionManual Assertion Based On ExperimentIMP:ARUK-UCL
Memory T cell extravasationManual Assertion Based On ExperimentIDA:ARUK-UCL
PhagocytosisIEA:UniProtKB-KW
Receptor clusteringManual Assertion Based On ExperimentIMP:UniProtKB
Signal transduction1 PublicationNAS:UniProtKB
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 26-1090
Helical: 1091-1111
Cytoplasmic: 1112-1170
PTM
In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents.

Anti-ITGAL antibodies

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Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG119
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: AG118
Application*: F, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AG117
Application*: F, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A679
Application*: FC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: A678
Application*: FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 564
Application*: ELISA, IHC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CAP1040
Application*: FC, ICC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI(SPV)-L7
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NKI(SPV)-L16
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CAP908
Application*: FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BU85
Application*: IHC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: A677
Application*: FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF248
Application*: ELISA, IHC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB282
Application*: IF, FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB281
Application*: IF, FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB280
Application*: IF, FC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Hamster, Rabbit
Clone: TS1/22
Application*: B, E, F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: MAB0812
Application*: B
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI SPV-L1
Application*: IF/IC, IP, F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: YTH81.5
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: R7.1
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: WT.1
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NKISPV-L15
Application*: WB, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0158
Application*: F, C, FN, IA, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI-SPV-L7
Application*: IP, FC, FN, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NKI-SPV-L15
Application*: FC, IP, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: NKI-SPV-L1
Application*: IH, IP, FC, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D247
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F13
Application*: FC, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse, Rabbit, Sheep
Clone: 3H934
Application*: FC, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 13H37
Application*: FC, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: OFYS
Application*: FC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBWJC-3874
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3872
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3871
Application*: F, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3870
Application*: F, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3869
Application*: F, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: IBL-6/2
Application*: C, IP, F
Target: ITGAL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2231
Application*: F, B, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Dog, Rabbit
Clone: HI111
Application*: F, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-2230
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBWJC-2229
Application*: F
Target: ITGAL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBWJC-2228
Application*: WB, IP, P, C, F, IC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse
Clone: CVS9
Application*: F, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Cattle, Pig, Sheep
Clone: BL1H8
Application*: F, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: BU85
Application*: IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BU17
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-83
Application*: F, IP, FN
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: CBXC-2620
Application*: IC
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXC-1547
Application*: F, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBXC-1662
Application*: F, IH
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBXC-1626
Application*: F, IH, IP, WB
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXC-1598
Application*: F, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MEM-25
Application*: F
Target: ITGAL
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0831
Application*: F
Target: ITGAL
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: hu1124 (Efalizumab)
Application*: F, N, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: CBYY-C2601
Application*: F, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C2600
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-C0198
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-C0196
Application*: F, IH, IP, N
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CBFYC-2814
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2813
Application*: WB, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2812
Application*: F, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2811
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0543
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Cattle, Goat, Sheep
Clone: CBFYC-0187
Application*: F, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1593
Application*: F, IF, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0851
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0498
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: CBYY-I0493
Application*: F, IH, IP, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0479
Application*: F, E
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0382
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0319
Application*: F, IP, FN, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0317
Application*: BL, F, FN, IP, N, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0268
Application*: E, F, IF, C, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBYY-I0267
Application*: F, C, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: I21/7
Application*: F, IH, IP, C, BL, N, IC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: DF1524
Application*: IF, F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CRIS-3
Application*: E, F, FN, IF, C, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Dog
Clone: CA11.4D3
Application*: F, IH, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-I0026
Application*: F, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CR38
Application*: F, MC
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-I0015
Application*: F, IH, C, FN, WB, IF, E
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8H155
Application*: C, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 87-6F9
Application*: F, C
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 8-6.2
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 7H117
Application*: C, WB
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 5K221
Application*: F, IH, IP, WB
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5K215
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 27/CD11a
Application*: WB, IF
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 14J11
Application*: F, IF, IH
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 122
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Horse
Clone: 10B593
Application*: F, IH
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 10B584
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG1
Specificity: Cat
Clone: 10B577
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 3H945
Application*: F
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Rat
Clone: 3H942
Application*: F, IH, IP
Target: ITGAL
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3H941
Application*: F, IH, IP
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: 2D7
Application*: F
Target: ITGAL
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 121/7
Application*: F, I, N
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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