ITGA2

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Full Name

Integrin Subunit Alpha 2

Function

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A.
(Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.

Biological Process

Animal organ morphogenesisManual Assertion Based On ExperimentTAS:ProtInc
Blood coagulationManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesionManual Assertion Based On ExperimentTAS:ProtInc
Cell adhesion mediated by integrinManual Assertion Based On ExperimentIMP:UniProtKB
Cell population proliferationIEA:Ensembl
Cell-matrix adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to estradiol stimulusIEA:Ensembl
Cellular response to mechanical stimulusIEA:Ensembl
Collagen-activated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Detection of mechanical stimulus involved in sensory perception of painIEA:Ensembl
Establishment of protein localizationIEA:Ensembl
Female pregnancyIEA:Ensembl
Focal adhesion assemblyIEA:Ensembl
Hepatocyte differentiationIEA:Ensembl
Hypotonic responseIEA:Ensembl
Integrin-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Mammary gland developmentIEA:Ensembl
Mesodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Positive regulation of alkaline phosphatase activityIEA:Ensembl
Positive regulation of cell adhesionIEA:Ensembl
Positive regulation of cell projection organizationIEA:Ensembl
Positive regulation of collagen bindingIEA:Ensembl
Positive regulation of collagen biosynthetic processIEA:Ensembl
Positive regulation of DNA bindingIEA:Ensembl
Positive regulation of epithelial cell migrationIEA:Ensembl
Positive regulation of inflammatory responseIEA:Ensembl
Positive regulation of leukocyte migrationIEA:Ensembl
Positive regulation of phagocytosis, engulfmentIEA:Ensembl
Positive regulation of positive chemotaxisIEA:Ensembl
Positive regulation of smooth muscle cell migrationIEA:Ensembl
Positive regulation of smooth muscle cell proliferationIEA:Ensembl
Positive regulation of smooth muscle contractionIEA:Ensembl
Positive regulation of translationIEA:Ensembl
Positive regulation of transmission of nerve impulseIEA:Ensembl
Response to amineIEA:Ensembl
Response to hypoxiaIEA:Ensembl
Response to L-ascorbic acidIEA:Ensembl
Response to muscle activityIEA:Ensembl
Response to parathyroid hormoneIEA:Ensembl
Response to xenobiotic stimulusIEA:Ensembl
Skin morphogenesisIEA:Ensembl
Substrate-dependent cell migrationManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 30-1132
Helical: 1133-1154
Cytoplasmic: 1155-1181

Anti-ITGA2 antibodies

Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)