INHBB

This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activate and inhibit, respectively, follicle stimulating hormone secretion from the pituitary gland. Polymorphisms near this gene are associated with pre-eclampsia in female human patients. [provided by RefSeq, Aug 2016]

Full Name

Inhibin Beta B Subunit

Function

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.

Biological Process

Activin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cellular response to calcium ionIEA:Ensembl
Cellular response to cAMPIEA:Ensembl
Cellular response to cholesterolIEA:Ensembl
Cellular response to insulin stimulusISS:UniProtKB
Cellular response to interleukin-1IEA:Ensembl
Cellular response to leptin stimulusIEA:Ensembl
Cellular response to starvationISS:UniProtKB
Cellular response to Thyroglobulin triiodothyronineIEA:Ensembl
Cellular response to thyroid hormone stimulusIEA:Ensembl
Defense responseManual Assertion Based On ExperimentTAS:UniProtKB
Fat cell differentiationISS:UniProtKB
Negative regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIPI:UniProtKB
Negative regulation of hepatocyte growth factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of insulin secretionISS:UniProtKB
Oocyte developmentIEA:Ensembl
Ovarian follicle development1 PublicationNAS:UniProtKB
Pituitary gland developmentIEA:Ensembl
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIPI:UniProtKB
Positive regulation of ovulationISS:UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Reproductive senescenceIEA:Ensembl
Response to gonadotropinIEA:Ensembl
Response to insecticideIEA:Ensembl
Response to woundingManual Assertion Based On ExperimentIEP:UniProtKB
Seminiferous tubule developmentIEA:Ensembl
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
SpermatogenesisIEA:Ensembl

Cellular Location

Secreted