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Mouse Anti-INHBB Recombinant Antibody (146807) (CBMAB-0375CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
146807
Antibody Isotype
IgG1
Application
WB, Block

Basic Information

Immunogen
Chinese hamster ovary cell line CHO-derived recombinant human Activin B (Gly293-Ala407)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inhibin Beta B Subunit
Introduction
The activins, dimers of beta-A or beta-B subunits encoded by the genes Inhba (147290) and Inhbb, respectively, are TGF-beta (see 190180) superfamily members that have roles in reproduction and development. The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. Lafuse and Zwilling (1993) mapped the Inhbb gene to mouse chromosome 1 by study of recombinant inbred strains. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion.
Entrez Gene ID
3625
UniProt ID
P09529
Alternative Names
Inhibin beta B subunit
Function
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Biological Process
Activin receptor signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Cell differentiation1 PublicationNAS:UniProtKB
Cellular response to calcium ionIEA:Ensembl
Cellular response to cAMPIEA:Ensembl
Cellular response to cholesterolIEA:Ensembl
Cellular response to insulin stimulusISS:UniProtKB
Cellular response to interleukin-1IEA:Ensembl
Cellular response to leptin stimulusIEA:Ensembl
Cellular response to starvationISS:UniProtKB
Cellular response to Thyroglobulin triiodothyronineIEA:Ensembl
Cellular response to thyroid hormone stimulusIEA:Ensembl
Defense responseManual Assertion Based On ExperimentTAS:UniProtKB
Fat cell differentiationISS:UniProtKB
Negative regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIPI:UniProtKB
Negative regulation of hepatocyte growth factor productionManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of insulin secretionISS:UniProtKB
Oocyte developmentIEA:Ensembl
Ovarian follicle development1 PublicationNAS:UniProtKB
Pituitary gland developmentIEA:Ensembl
Positive regulation of apoptotic signaling pathwayIEA:Ensembl
Positive regulation of follicle-stimulating hormone secretionManual Assertion Based On ExperimentIPI:UniProtKB
Positive regulation of ovulationISS:UniProtKB
Positive regulation of pathway-restricted SMAD protein phosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Reproductive senescenceIEA:Ensembl
Response to gonadotropinIEA:Ensembl
Response to insecticideIEA:Ensembl
Response to woundingManual Assertion Based On ExperimentIEP:UniProtKB
Seminiferous tubule developmentIEA:Ensembl
SMAD protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
SpermatogenesisIEA:Ensembl
Cellular Location
Secreted
More Infomation

Zhang, H., Wang, Z., Zhou, Q., Cao, Z., Jiang, Y., Xu, M., ... & Sun, H. (2023). Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway. Journal of Assisted Reproduction and Genetics, 1-12.

Yang, X., Jia, Q., Zou, Z., Liu, X., Li, X., Chen, H., ... & Chen, L. (2023). INHBB promotes tumor aggressiveness and stemness of glioblastoma via activating EGFR signaling. Pathology-Research and Practice, 245, 154460.

Zhang, H., Zhang, X., & Wang, Z. (2023). P-517 Downregulated INHBB in endometrial tissue of recurrent implantation failure patients impeded decidualization through the ADCY1/cAMP signalling pathway. Human Reproduction, 38(Supplement_1), dead093-860.

Sun, Y., Cai, H., Ge, J., Shao, F., Huang, Z., Ding, Z., ... & Zang, Y. (2022). Tubule‐derived INHBB promotes interstitial fibroblast activation and renal fibrosis. The Journal of pathology, 256(1), 25-37.

Houston, B. J., O’Connor, A. E., Wang, D., Goodchild, G., Merriner, D. J., Luan, H., ... & Walton, K. (2022). Human INHBB gene variant (c. 1079T> C: p. Met360Thr) alters testis germ cell content, but does not impact fertility in mice. Endocrinology, 163(3), bqab269.

Yu, W., He, G., Zhang, W., Ye, Z., Zhong, Z., & Huang, S. (2022). INHBB is a novel prognostic biomarker and correlated with immune infiltrates in gastric cancer. Frontiers in Genetics, 13, 933862.

Chen, Y., Qian, B., Sun, X., Kang, Z., Huang, Z., Ding, Z., ... & Zang, Y. (2021). Sox9/INHBB axis-mediated crosstalk between the hepatoma and hepatic stellate cells promotes the metastasis of hepatocellular carcinoma. Cancer letters, 499, 243-254.

Damavandi, M., Farrokh, P., & Zavareh, S. (2021). Effect of mouse ovarian vitrification on promoter methylation of inhba and inhbb in granulosa cells of follicles. Cryoletters, 42(2), 67-72.

Yuan, J., Xie, A., Cao, Q., Li, X., & Chen, J. (2020). INHBB is a novel prognostic biomarker associated with cancer-promoting pathways in colorectal cancer. BioMed research international, 2020.

Zheng, L., Lu, H., Li, H., Xu, X., & Wang, D. (2020). KLF10 is upregulated in osteoarthritis and inhibits chondrocyte proliferation and migration by upregulating Acvr1 and suppressing inhbb expression. Acta histochemica, 122(3), 151528.

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For research use only. Not intended for any clinical use.

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