IL27RA

In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein. [provided by RefSeq]

interleukin 27 receptor, alpha

Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761).
Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.

Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-17 productionIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell extravasationIEA:Ensembl
Negative regulation of T-helper 17 type immune responseIEA:Ensembl
Negative regulation of tumor necrosis factor productionIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of activated T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of interferon-gamma productionIEA:Ensembl
Positive regulation of T-helper 1 type immune responseIEA:Ensembl
Regulation of isotype switching to IgG isotypesIEA:Ensembl

Membrane

Extracellular: 33-516
Helical: 517-537
Cytoplasmic: 538-636