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Rat Anti-Il27ra Recombinant Antibody (CBYJT-2214) (CBMAB-T1320-YJ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYJT-2214
Antibody Isotype
IgG2b
Application
FC, WB

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse IL-27 R alpha/WSX-1/TCCR Gly29-Lys510
Specificity
Mouse
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 5% Trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 29-510

Target

Full Name
interleukin 27 receptor, alpha
Introduction
Il27ra is a receptor for IL27. It requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. It is Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Entrez Gene ID
50931
UniProt ID
O70394
Alternative Names
CRL1; Tccr; Wsx1; WSX-1; IL-27R; zcytor1
Function
Receptor for IL27. Requires IL6ST/GP130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL6ST/GP130 and CNTFR (PubMed:19386761).
Involved in the regulation of Th1-type immune responses. Also appears to be involved in innate defense mechanisms.
Biological Process
Cell surface receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-positive bacteriumIEA:Ensembl
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Negative regulation of interleukin-17 productionIEA:Ensembl
Negative regulation of interleukin-6 productionIEA:Ensembl
Negative regulation of neuron apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of T cell extravasationIEA:Ensembl
Negative regulation of T-helper 17 type immune responseIEA:Ensembl
Negative regulation of tumor necrosis factor productionIEA:Ensembl
Negative regulation of type 2 immune responseIEA:Ensembl
Positive regulation of activated T cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of interferon-gamma productionIEA:Ensembl
Positive regulation of T-helper 1 type immune responseIEA:Ensembl
Regulation of isotype switching to IgG isotypesIEA:Ensembl
Cellular Location
Membrane
Topology
Extracellular: 33-516
Helical: 517-537
Cytoplasmic: 538-636
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For research use only. Not intended for any clinical use.

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