IL24

This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Interleukin 24

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.

Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-4IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Negative regulation of cell migrationIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinIEA:Ensembl
Serine phosphorylation of STAT proteinIEA:Ensembl
Wound healingIEA:Ensembl

Secreted

Ubiquitination at Lys-122 promotes proteasomal degradation.