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Mouse Anti-IL24 Recombinant Antibody (CBYY-I0889) (CBMAB-I2057-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0889
Antibody Isotype
IgG2b, κ
Application
ELISA, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 24
Introduction
This gene encodes a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. The protein encoded by this gene can induce apoptosis selectively in various cancer cells. Overexpression of this gene leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
Entrez Gene ID
11009
UniProt ID
Q13007
Alternative Names
Interleukin 24
Function
Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
Biological Process
Apoptotic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular response to interleukin-4IEA:Ensembl
Cellular response to lipopolysaccharideIEA:Ensembl
Negative regulation of cell migrationIEA:Ensembl
Negative regulation of cell population proliferationIEA:Ensembl
Positive regulation of cell population proliferationIEA:Ensembl
Positive regulation of tyrosine phosphorylation of STAT proteinIEA:Ensembl
Serine phosphorylation of STAT proteinIEA:Ensembl
Wound healingIEA:Ensembl
Cellular Location
Secreted
PTM
Ubiquitination at Lys-122 promotes proteasomal degradation.
More Infomation

Sie, C., Kant, R., Peter, C., Muschaweckh, A., Pfaller, M., Nirschl, L., ... & Korn, T. (2022). IL-24 intrinsically regulates Th17 cell pathogenicity in mice. Journal of Experimental Medicine, 219(8), e20212443.

Feng, K. N., Meng, P., Zou, X. L., Zhang, M., Li, H. K., Yang, H. L., ... & Zhang, T. T. (2022). IL-37 protects against airway remodeling by reversing bronchial epithelial–mesenchymal transition via IL-24 signaling pathway in chronic asthma. Respiratory Research, 23(1), 1-17.

Davidson, S., Yu, C. H., Steiner, A., Ebstein, F., Baker, P. J., Jarur-Chamy, V., ... & Masters, S. L. (2022). Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24. Science Immunology, 7(68), eabi6763.

Chong, W. P., Mattapallil, M. J., Raychaudhuri, K., Bing, S. J., Wu, S., Zhong, Y., ... & Caspi, R. R. (2020). The cytokine IL-17A limits Th17 pathogenicity via a negative feedback loop driven by autocrine induction of IL-24. Immunity, 53(2), 384-397.

Emdad, L., Bhoopathi, P., Talukdar, S., Pradhan, A. K., Sarkar, D., Wang, X. Y., ... & Fisher, P. B. (2020, November). Recent insights into apoptosis and toxic autophagy: The roles of MDA-7/IL-24, a multidimensional anti-cancer therapeutic. In Seminars in cancer biology (Vol. 66, pp. 140-154). Academic Press.

Mitamura, Y., Nunomura, S., Furue, M., & Izuhara, K. (2020). IL-24: A new player in the pathogenesis of pro-inflammatory and allergic skin diseases. Allergology International, 69(3), 405-411.

Schmetzer, O., Lakin, E., Topal, F. A., Preusse, P., Freier, D., Church, M. K., & Maurer, M. (2018). IL-24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria. Journal of Allergy and Clinical Immunology, 142(3), 876-882.

Mitamura, Y., Nunomura, S., Nanri, Y., Ogawa, M., Yoshihara, T., Masuoka, M., ... & Izuhara, K. (2018). The IL‐13/periostin/IL‐24 pathway causes epidermal barrier dysfunction in allergic skin inflammation. Allergy, 73(9), 1881-1891.

Menezes, M. E., Bhoopathi, P., Pradhan, A. K., Emdad, L., Das, S. K., Guo, C., ... & Fisher, P. B. (2018). Role of MDA-7/IL-24 a multifunction protein in human diseases. Advances in cancer research, 138, 143-182.

Pradhan, A. K., Bhoopathi, P., Talukdar, S., Shen, X. N., Emdad, L., Das, S. K., ... & Fisher, P. B. (2018). Recombinant MDA-7/IL24 suppresses prostate cancer bone metastasis through downregulation of the Akt/Mcl-1 pathway. Molecular cancer therapeutics, 17(9), 1951-1960.

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For research use only. Not intended for any clinical use.

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