IGFBP2

The protein encoded by this gene is one of six similar proteins that bind insulin-like growth factors I and II (IGF-I and IGF-II). The encoded protein can be secreted into the bloodstream, where it binds IGF-I and IGF-II with high affinity, or it can remain intracellular, interacting with many different ligands. High expression levels of this protein promote the growth of several types of tumors and may be predictive of the chances of recovery of the patient. Several transcript variants, one encoding a secreted isoform and the others encoding nonsecreted isoforms, have been found for this gene. [provided by RefSeq, Sep 2015]

Insulin Like Growth Factor Binding Protein 2

Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Aging Source: Ensembl
Cellular response to hormone stimulus Source: Ensembl
Female pregnancy Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of activated T cell proliferation Source: BHF-UCL
Regulation of growth Source: UniProtKB-KW
Regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
Response to estradiol Source: Ensembl
Response to estrogen Source: Ensembl
Response to glucocorticoid Source: Ensembl
Response to lithium ion Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Response to nutrient Source: Ensembl
Response to retinoic acid Source: Ensembl
Response to xenobiotic stimulus Source: Ensembl
Signal transduction Source: Ensembl

Secreted

O-glycosylated.