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IDO1

This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]

Full Name

Indoleamine 2,3-Dioxygenase 1

Function

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174).

Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885).

Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885).

Acts as a suppressor of anti-tumor immunity (PubMed:23103127, PubMed:25157255, PubMed:14502282, PubMed:25691885).

Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885).

Protects the fetus from maternal immune rejection (PubMed:25691885).

Biological Process

de novo' NAD biosynthetic process from tryptophan Source: GO_Central
Female pregnancy Source: ProtInc
Immune system process Source: UniProtKB-KW
Inflammatory response Source: Ensembl
Kynurenic acid biosynthetic process Source: Ensembl
Multicellular organismal response to stress Source: Ensembl
Negative regulation of interleukin-10 production Source: Ensembl
Negative regulation of T cell apoptotic process Source: Ensembl
Negative regulation of T cell proliferation Source: Ensembl
Positive regulation of chronic inflammatory response Source: Ensembl
Positive regulation of interleukin-12 production Source: Ensembl
Positive regulation of T cell apoptotic process Source: UniProtKB
Positive regulation of T cell tolerance induction Source: Ensembl
Positive regulation of type 2 immune response Source: Ensembl
Response to lipopolysaccharide Source: Ensembl
Swimming behavior Source: Ensembl
Tryptophan catabolic process Source: ProtInc
Tryptophan catabolic process to kynurenine Source: GO_Central

Cellular Location

Cytosol

Anti-IDO1 antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-IDO1 Recombinant Antibody (A383) (CBMAB-AP10824LY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: A383

Application*: IF, IHC, IP, WB

Rabbit Anti-IDO1 Recombinant Antibody (CBR031F) (CBMAB-BT048LY)

SDS

Target: IDO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBR031F

Application*: WB, IHC, ICC, IHC-IF

Rabbit Anti-IDO1 Recombinant Antibody (CBR040F) (CBMAB-BT047LY)

SDS

Target: IDO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBR040F

Application*: WB, IP

Rabbit Anti-IDO1 Recombinant Antibody (D7Z7U) (CBMAB-CP1172-LY)

SDS

Target: IDO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: D7Z7U

Application*: WB, IP, F

Rabbit Anti-IDO1 Recombinant Antibody (D8W5E) (CBMAB-CP1171-LY)

SDS

Target: IDO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: D8W5E

Application*: WB, IP, IF (IC)

Rabbit Anti-IDO1 Recombinant Antibody (D5J4E) (CBMAB-CP1170-LY)

SDS

Target: IDO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D5J4E

Application*: WB, IP, IH, P, IF (IC), F

Mouse Anti-IDO1 Recombinant Antibody (4C9) (CBMAB-A4231-LY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4C9

Application*: WB, E

Mouse Anti-IDO1 Recombinant Antibody (3F3) (CBMAB-A4228-LY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F3

Application*: WB, E

Mouse Anti-IDO1 Recombinant Antibody (1C1) (CBMAB-A4225-LY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1C1

Application*: E, E

Recombinant Mouse Anti-Ido1 Recombinant Antibody (8G11) (CBMAB-XB0582-YC)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: 8G11

Application*: F, WB

Mouse Anti-IDO1 Recombinant Antibody (CBYY-I2147) (CBMAB-I3317-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I2147

Application*: IH

Mouse Anti-IDO1 Recombinant Antibody (CBYY-I1932) (CBMAB-I3102-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1932

Application*: WB, IF

Mouse Anti-IDO1 Recombinant Antibody (CBYY-I1890) (CBMAB-I3060-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-I1890

Application*: WB, IH, IF

Rabbit Anti-IDO1 Recombinant Antibody (CBYY-I1770) (CBMAB-I2940-YY)

SDS

Target: IDO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYY-I1770

Application*: WB

Mouse Anti-IDO1 Recombinant Antibody (9i171) (CBMAB-I1842-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 9i171

Application*: WB, IH

Mouse Anti-IDO1 Recombinant Antibody (700838) (CBMAB-I1598-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 700838

Application*: IS, IC, MC

Mouse Anti-IDO1 Recombinant Antibody (4F9) (CBMAB-I1342-YY)

SDS

Target: IDO1

Host: Mouse

Specificity: Human

Clone: 4F9

Application*: E, WB

Mouse Anti-IDO1 Recombinant Antibody (4D2) (CBMAB-I1323-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4D2

Application*: E, P, WB

Mouse Anti-IDO1 Recombinant Antibody (CBYY-I0485) (CBMAB-I1132-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBYY-I0485

Application*: IC, IF, P

Rat Anti-IDO1 Recombinant Antibody (mIDO-48) (CBMAB-I0872-YY)

SDS

Target: IDO1

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse

Clone: mIDO-48

Application*: WB, P, C

Mouse Anti-IDO1 Recombinant Antibody (ID 177) (CBMAB-I0250-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: ID 177

Application*: E, WB, P

Mouse Anti-IDO1 Recombinant Antibody (CBYY-I0092) (CBMAB-I0249-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: CBYY-I0092

Application*: IS

Mouse Anti-IDO1 Recombinant Antibody (2E2.6) (CBMAB-I0248-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: 2E2.6

Application*: E, F, IF, IP, WB, P

Mouse Anti-IDO1 Recombinant Antibody (2B5) (CBMAB-I0247-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2B5

Application*: WB, IH, IF, P

Mouse Anti-IDO1 Recombinant Antibody (1A3) (CBMAB-I0246-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1A3

Application*: IF, P, WB

Mouse Anti-IDO1 Recombinant Antibody (10.1) (CBMAB-I0245-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG3

Specificity: Mouse, Human

Clone: 10.1

Application*: E, IH, IF, IP, WB, C

Mouse Anti-IDO1 Recombinant Antibody (CBYY-I0010) (CBMAB-I0015-YY)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYY-I0010

Application*: F

Mouse Anti-IDO1 Antibody (7BA22) (CBMAB-1332CQ)

SDS

Target: IDO1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 7BA22

Application*: E

IDO1 Matched Antibody Pair (586) (APMAB-586LY)

SDS

Target: IDO1

Specificity: Human

IDO1 Matched Antibody Pair (585) (APMAB-585LY)

SDS

Target: IDO1

Specificity: Human

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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