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IDO1 Matched Antibody Pair (585) (APMAB-585LY)


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Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-IDO1 polyclonal antibody, 100 ug
Detection Antibody
Anti-IDO1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
Alternative Names
Indoleamine 2,3-Dioxygenase 1
Entrez Gene ID
3620
UniProt ID
P14902
More Infomation

Salminen, A. (2022). Role of indoleamine 2, 3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process. Ageing Research Reviews, 75, 101573.

Pallotta, M. T., Rossini, S., Suvieri, C., Coletti, A., Orabona, C., Macchiarulo, A., ... & Grohmann, U. (2022). Indoleamine 2, 3‐dioxygenase 1 (IDO1): an up‐to‐date overview of an eclectic immunoregulatory enzyme. The FEBS journal, 289(20), 6099-6118.

Fujiwara, Y., Kato, S., Nesline, M. K., Conroy, J. M., DePietro, P., Pabla, S., & Kurzrock, R. (2022). Indoleamine 2, 3-dioxygenase (IDO) inhibitors and cancer immunotherapy. Cancer Treatment Reviews, 102461.

Zhang, Y., Hu, Z., Zhang, J., Ren, C., & Wang, Y. (2022). Dual-target inhibitors of indoleamine 2, 3 dioxygenase 1 (Ido1): A promising direction in cancer immunotherapy. European Journal of Medicinal Chemistry, 238, 114524.

Tang, K., Wu, Y. H., Song, Y., & Yu, B. (2021). Indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy. Journal of Hematology & Oncology, 14, 1-21.

Röhrig, U. F., Michielin, O., & Zoete, V. (2021). Structure and plasticity of indoleamine 2, 3-dioxygenase 1 (IDO1). Journal of Medicinal Chemistry, 64(24), 17690-17705.

Wang, X. X., Sun, S. Y., Dong, Q. Q., Wu, X. X., Tang, W., & Xing, Y. Q. (2019). Recent advances in the discovery of indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors. MedChemComm, 10(10), 1740-1754.

Röhrig, U. F., Reynaud, A., Majjigapu, S. R., Vogel, P., Pojer, F., & Zoete, V. (2019). Inhibition mechanisms of indoleamine 2, 3-dioxygenase 1 (IDO1). Journal of medicinal chemistry, 62(19), 8784-8795.

Nayak-Kapoor, A., Hao, Z., Sadek, R., Dobbins, R., Marshall, L., Vahanian, N. N., ... & Khleif, S. N. (2018). Phase Ia study of the indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitor navoximod (GDC-0919) in patients with recurrent advanced solid tumors. Journal for immunotherapy of cancer, 6(1), 1-12.

Komiya, T., & Huang, C. H. (2018). Updates in the clinical development of epacadostat and other indoleamine 2, 3-dioxygenase 1 inhibitors (IDO1) for human cancers. Frontiers in oncology, 8, 423.

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For research use only. Not intended for any clinical use.

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