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ICAM1

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor
Full Name
Intercellular Adhesion Molecule 1
Alternative Names
Intercellular Adhesion Molecule 1
Function
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.

(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins.

(Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins.

(Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell.
Biological Process
Adhesion of symbiont to host Source: BHF-UCL
Cell adhesion Source: BHF-UCL
Cell adhesion mediated by integrin Source: Ensembl
Cellular response to amyloid-beta Source: ARUK-UCL
Cellular response to glucose stimulus Source: Ensembl
Cellular response to leukemia inhibitory factor Source: Ensembl
Establishment of endothelial barrier Source: UniProtKB
Heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: BHF-UCL
Leukocyte cell-cell adhesion Source: BHF-UCL
Leukocyte migration Source: BHF-UCL
Membrane to membrane docking Source: BHF-UCL
Negative regulation of endothelial cell apoptotic process Source: BHF-UCL
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
Positive regulation of cellular extravasation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Receptor-mediated virion attachment to host cell Source: BHF-UCL
Regulation of leukocyte mediated cytotoxicity Source: BHF-UCL
Regulation of ruffle assembly Source: Ensembl
T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell Source: BHF-UCL
T cell antigen processing and presentation Source: Ensembl
T cell extravasation Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 28-480
Helical: 481-503
Cytoplasmic: 504-532
PTM
Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.

Anti-ICAM1 antibodies

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Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AG86
Application*: F, IH, IP, WB
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: AG88
Application*: B, IP, WB
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: AG87
Application*: MC, F, C, IP, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF211
Application*: ELISA, IHC, WB, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb131
Application*: WB, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P2A4
Application*: E, F, B, IF, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R6-5-D6
Application*: A, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A361
Application*: ICC, IHC, IP, WB
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A360
Application*: ICC, IF, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A359
Application*: ICC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A358
Application*: ELISA, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A357
Application*: FC, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A356
Application*: IF, IHC, WB
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: A355
Application*: ICC, IF, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: A354
Application*: IF, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A353
Application*: ELISA, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: A351
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A350
Application*: FC, IF, IHC, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: A349
Application*: FC, IHC, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: A348
Application*: ELISA, IF, IHC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A347
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: F4-31C2
Application*: FA, FC, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP906
Application*: ICC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LT54
Application*: FC, IP
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: A352
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB459A
Application*: ELISA, WB, ICC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB427A
Application*: ELISA, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB109A
Application*: ELISA, IHC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB260
Application*: IF, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB259
Application*: IF, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CB258
Application*: IF, FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: LB-2
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb133
Application*: WB, IH, FC
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb132
Application*: WB, IH, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: W-CAM-1
Application*: E, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R6.1
Application*: E
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: RR1/1
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: R6-5-D6
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYA-0117
Application*: F, C, IA, IF, IP, P
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: WK1
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G155
Application*: IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9G154
Application*: IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5J278
Application*: FC, IF, IH, N, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1546
Application*: E, FC, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14L220
Application*: E, IH, WB
Target: ICAM1
Host: Sheep
Specificity: Human
Clone: 12G2
Application*: E, DB, IH, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.BB.478
Application*: FC
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6A507
Application*: IF, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 0.N.147
Application*: IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3780
Application*: IP, IC, E, P, C
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-3778
Application*: F, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJC-3777
Application*: FN, F, IF
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: CBWJC-3776
Application*: F, FN, C, P, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-3775
Application*: C, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBWJC-2181
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2180
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2179
Application*: F, IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: B-H22
Application*: E
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P1W16
Application*: F, IH, IF, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: BU74
Application*: F, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1838
Application*: F, IP, E, FN
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1474
Application*: F, IH
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXC-1473
Application*: F, IP
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBXC-1620
Application*: F, IH, IP, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-2033
Application*: F
Target: ICAM1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0781
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2541
Application*: IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Pig
Clone: CBYY-C2540
Application*: E, F, IH, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2539
Application*: E, WB
Target: ICAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-C2536
Application*: E, F, IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2535
Application*: F, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2534
Application*: F, IH, IP, WB
Target: ICAM1
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYY-C2533
Application*: C, E, FN, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0609
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0544
Application*: E, F, IH, WB
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: CBYY-C0426
Application*: F, IH, IP, WB
Target: ICAM1
Host: Hamster
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C0072
Application*: F, C
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-2745
Application*: IC, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYC-2744
Application*: E, F, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2743
Application*: F, IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYC-2742
Application*: F, IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2741
Application*: WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2740
Application*: P, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2739
Application*: WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-2737
Application*: E, F, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYC-2736
Application*: WB, IC, P, C, E, IP, IF, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0411
Application*: F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Rat
Clone: CBFYC-0359
Application*: F, IH
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-0261
Application*: C, WB, F, P
Target: ICAM1
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-0140
Application*: F, IH, IP
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0003
Application*: F, IH, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2005
Application*: WB, IH
Target: ICAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-I1423
Application*: F, WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1359
Application*: WB
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBYY-I1160
Application*: WB, P
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1105
Application*: IP, E, C, F
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0937
Application*: E
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0927
Application*: WB, IF
Target: ICAM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig
Clone: CBYY-I0901
Application*: WB, P
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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