HTR2B
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210).
Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538).
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538).
Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538).
Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538).
Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity).
Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162).
Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).
Biological Process
Activation of phospholipase C activity Source: UniProtKB
Behavior Source: UniProtKB-KW
Calcium-mediated signaling Source: UniProtKB
Cardiac muscle hypertrophy Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
Cellular response to temperature stimulus Source: UniProtKB
cGMP-mediated signaling Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Embryonic morphogenesis Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
G protein-coupled receptor internalization Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
Heart morphogenesis Source: UniProtKB
Intestine smooth muscle contraction Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of autophagy Source: UniProtKB
Negative regulation of cell death Source: UniProtKB
Neural crest cell differentiation Source: UniProtKB
Neural crest cell migration Source: UniProtKB
Phosphatidylinositol 3-kinase signaling Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating serotonin receptor signaling pathway Source: UniProtKB
Phosphorylation Source: UniProtKB
Positive regulation of cell division Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of nitric-oxide synthase activity Source: UniProtKB
Positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Protein kinase C signaling Source: UniProtKB
Regulation of behavior Source: UniProtKB
Release of sequestered calcium ion into cytosol Source: UniProtKB
Response to xenobiotic stimulus Source: UniProtKB
Vasoconstriction Source: UniProtKB
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Datasheet