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Mouse Anti-HTR2B (AA 1-56) Recombinant Antibody (CBFYH-2498) (CBMAB-H3512-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2498
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
HTR2B AA 1-56 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-56

Target

Full Name
5-Hydroxytryptamine Receptor 2B
Introduction
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved. Alternatively spliced transcript variants have been found for this gene.
Entrez Gene ID
3357
UniProt ID
P41595
Alternative Names
5-Hydroxytryptamine Receptor 2B; 5-Hydroxytryptamine (Serotonin) Receptor 2B, G Protein-Coupled; Serotonin Receptor 2B; 5-HT-2B; 5-HT2B; 5-Hydroxytryptamine (Serotonin) Receptor 2B
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519210).

Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:8143856, PubMed:7926008, PubMed:8078486, PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538).

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:23519215, PubMed:28129538).

Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538).

Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores (PubMed:8143856, PubMed:8078486, PubMed:8882600, PubMed:18703043, PubMed:23519215, PubMed:28129538).

Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity).

Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162).

Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity).
Biological Process
Activation of phospholipase C activity Source: UniProtKB
Behavior Source: UniProtKB-KW
Calcium-mediated signaling Source: UniProtKB
Cardiac muscle hypertrophy Source: UniProtKB
Cellular calcium ion homeostasis Source: UniProtKB
Cellular response to temperature stimulus Source: UniProtKB
cGMP-mediated signaling Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Embryonic morphogenesis Source: UniProtKB
ERK1 and ERK2 cascade Source: UniProtKB
G protein-coupled receptor internalization Source: Ensembl
G protein-coupled receptor signaling pathway Source: UniProtKB
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
G protein-coupled serotonin receptor signaling pathway Source: UniProtKB
Heart morphogenesis Source: UniProtKB
Intestine smooth muscle contraction Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of autophagy Source: UniProtKB
Negative regulation of cell death Source: UniProtKB
Neural crest cell differentiation Source: UniProtKB
Neural crest cell migration Source: UniProtKB
Phosphatidylinositol 3-kinase signaling Source: UniProtKB
Phospholipase C-activating G protein-coupled receptor signaling pathway Source: GO_Central
Phospholipase C-activating serotonin receptor signaling pathway Source: UniProtKB
Phosphorylation Source: UniProtKB
Positive regulation of cell division Source: UniProtKB
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of endothelial cell proliferation Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
Positive regulation of MAP kinase activity Source: UniProtKB
Positive regulation of nitric-oxide synthase activity Source: UniProtKB
Positive regulation of phosphatidylinositol biosynthetic process Source: UniProtKB
Protein kinase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Protein kinase C signaling Source: UniProtKB
Regulation of behavior Source: UniProtKB
Release of sequestered calcium ion into cytosol Source: UniProtKB
Response to xenobiotic stimulus Source: UniProtKB
Vasoconstriction Source: UniProtKB
Cellular Location
Cell membrane; Synaptosome
Topology
Extracellular: 1-56
Helical: 57-79
Cytoplasmic: 80-90
Helical: 91-113
Extracellular: 114-129
Helical: 130-151
Cytoplasmic: 152-171
Helical: 172-192
Extracellular: 193-216
Helical: 217-239
Cytoplasmic: 240-324
Helical: 325-345
Extracellular: 346-360
Helical: 361-382
Cytoplasmic: 383-481
More Infomation

De Logu, F., Maglie, R., Titiz, M., Poli, G., Landini, L., Marini, M., ... & André, E. (2023). miRNA-203b-3p Induces Acute and Chronic Pruritus through 5-HTR2B and TRPV4. Journal of Investigative Dermatology, 143(1), 142-153.

Faria, M., Bellot, M., Bedrossiantz, J., Ramírez, J. R. R., Prats, E., Garcia-Reyero, N., ... & Raldua, D. (2022). Environmental levels of carbaryl impair zebrafish larvae behaviour: The potential role of ADRA2B and HTR2B. Journal of hazardous materials, 431, 128563.

Kent, M. E., Hu, B., Eggleston, T. M., Squires, R. S., Zimmerman, K. A., Weiss, R. M., ... & Haskell, S. E. (2022). Hypersensitivity of Zebrafish htr2b Mutant Embryos to Sertraline Indicates a Role for Serotonin Signaling in Cardiac Development. Journal of cardiovascular pharmacology, 80(2), 261.

Choi, W. G., Choi, W., Oh, T. J., Cha, H. N., Hwang, I., Lee, Y. K., ... & Kim, H. (2021). Inhibiting serotonin signaling through HTR2B in visceral adipose tissue improves obesity-related insulin resistance. The Journal of Clinical Investigation, 131(23).

Lu, X., Fan, Y., Li, M., Chang, X., & Qian, J. (2021). HTR2B and SLC5A3 are specific markers in age-related osteoarthritis and involved in apoptosis and inflammation of osteoarthritis synovial cells. Frontiers in Molecular Biosciences, 8, 691602.

Yang, T., Wang, H., Li, Y., Zeng, Z., Shen, Y., Wan, C., ... & Wen, F. (2020). Serotonin receptors 5-HTR2A and 5-HTR2B are involved in cigarette smoke-induced airway inflammation, mucus hypersecretion and airway remodeling in mice. International immunopharmacology, 81, 106036.

Lacoste, J., Lamy, S., Ramoz, N., Ballon, N., Jehel, L., Maroteaux, L., & Thibaut, F. (2020). A positive association between a polymorphism in the HTR2B gene and cocaine-crack in a French Afro-Caribbean population. The World Journal of Biological Psychiatry, 21(10), 784-789.

Le-Bel, G., Benhassine, M., Landreville, S., & Guérin, S. L. (2019). Analysis of the proteasome activity and the turnover of the serotonin receptor 2B (HTR2B) in human uveal melanoma. Experimental Eye Research, 184, 72-77.

Montalvo-Ortiz, J. L., Zhou, H., D’Andrea, I., Maroteaux, L., Lori, A., Smith, A., ... & Gelernter, J. (2018). Translational studies support a role for serotonin 2B receptor (HTR2B) gene in aggression-related cannabis response. Molecular psychiatry, 23(12), 2277-2286.

Benhassine, M., & Guérin, S. L. (2018). Transcription of the human 5-hydroxytryptamine receptor 2B (HTR2B) gene is under the regulatory influence of the transcription factors NFI and RUNX1 in human uveal melanoma. International Journal of Molecular Sciences, 19(10), 3272.

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For research use only. Not intended for any clinical use.

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