HTATIP2

NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import.

HIV-1 Tat interactive protein 2, 30kDa

Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Import into nucleus Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of programmed cell death Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Protein autophosphorylation Source: MGI
Regulation of angiogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc

Cytoplasm; Nucleus envelope