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Mouse Anti-HTATIP2 Recombinant Antibody (CBYJT-1383) (CBMAB-T0405-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-1383
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HIV-1 Tat interactive protein 2, 30kDa
Introduction
HTATIP2 (HIV-1 Tat Interactive Protein 2) is a Protein Coding gene. Diseases related to HTATIP2 include Hepatocellular Carcinoma and Gnathodiaphyseal Dysplasia. Among its related pathways are Cytoskeletal Signaling and Apoptosis and Autophagy. Gene Ontology (GO) annotations related to HTATIP2 include oxidoreductase activity and NAD binding.
Entrez Gene ID
10553
UniProt ID
Q9BUP3
Alternative Names
HIV-1 Tat Interactive Protein 2; Short Chain Dehydrogenase/Reductase Family 44U, Member 1; HIV-1 Tat Interactive Protein 2, 30kDa; 30 KDa HIV-1 TAT-Interacting Protein; HIV-1 TAT-Interactive Protein 2; Tat-Interacting Protein (30kD); TIP30
Function
Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.
Biological Process
Angiogenesis Source: UniProtKB-KW
Apoptotic process Source: UniProtKB-KW
Cell differentiation Source: UniProtKB-KW
Import into nucleus Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Positive regulation of programmed cell death Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Protein autophosphorylation Source: MGI
Regulation of angiogenesis Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: ProtInc
Cellular Location
Cytoplasm; Nucleus envelope
More Infomation

Cardinale, C. J., Chang, X., Wei, Z., Qu, H. Q., Bradfield, J. P., Polychronakos, C., & Hakonarson, H. (2023). Genome-wide association study of the age of onset of type 1 diabetes reveals HTATIP2 as a novel T cell regulator. Frontiers in Immunology, 14, 1101488.

Nguyen, T. T., Rajakannu, P., Pham, M. D. T., Weman, L., Jucht, A., Buri, M. C., ... & Hegi, M. E. (2023). Epigenetic silencing of HTATIP2 in glioblastoma contributes to treatment resistance by enhancing nuclear translocation of the DNA‐repair protein N‐methylpurine DNA glycosylase (MPG). Molecular Oncology.

Hegi, M., Nguyen, T. T., Rajakannu, P., Pham, M. D. T., Weman, L., Jucht, A., ... & Van Dommelen, K. (2022). Epigenetic silencing of HTATIP2 in glioblastoma enhances nuclear translocation of the DNA-repair protein MPG affecting treatment resistance.

Zhang, X., Zhang, X., Li, X., Bao, H., Li, G., Li, N., ... & Dou, J. (2020). HTATIP2 Represents an Innovative Bio-marker in Hepatocellular Carcinoma Detection.

Zhao, B., Chen, Y., Hu, S., Yang, N., Liu, M., Li, J., ... & Wu, X. (2020). Characterization of HTATIP2 and its role during hair follicle cycles in Angora rabbit. Genome, 63(3), 179-187.

Li, M., Li, J., Guo, X., Pan, H., & Zhou, Q. (2020). Absence of HTATIP2 expression in A549 lung adenocarcinoma cells promotes tumor plasticity in response to hypoxic stress. Cancers, 12(6), 1538.

Zhang, P., Chen, Z., Chen, L., Zang, H., Zhu, B., Shao, W., & Niu, W. (2020). Clinical significance of changes in AFP, HTATIP2/TIP30, B7-H4 and inflammatory cytokines after transcatheter arterial chemoembolization. Journal of BUON, 25(2), 1206-1211.

Zheng, Z. J., Fu, J., Zhi, F., Liu, W. J., Guo, Y. J., Zhu, D. D., & Mo, J. G. (2018). The effects of interventional therapy on serum HTATIP2/TIP30, B7-H4 and short-term curative effect in primary hepatocellular carcinoma. Eur Rev Med Pharmacol Sci, 22(20), 6778-83.

Nanok, C., Jearanaikoon, P., Proungvitaya, S., & Limpaiboon, T. (2018). Aberrant methylation of HTATIP2 and UCHL1 as a predictive biomarker for cholangiocarcinoma. Molecular Medicine Reports, 17(3), 4145-4153.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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