HSPH1

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

Heat Shock Protein Family H (Hsp110) Member 1

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877).

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Chaperone cofactor-dependent protein refolding Source: Ensembl
Positive regulation of MHC class I biosynthetic process Source: BHF-UCL
Positive regulation of NK T cell activation Source: BHF-UCL
Response to unfolded protein Source: ProtInc

Cytoplasm

Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.