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HSPB8

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease.
Full Name
Heat Shock Protein Family B (Small) Member 8
Alternative Names
Heat Shock Protein Family B (Small) Member 8; Small Stress Protein-Like Protein HSP22; Heat Shock 27kDa Protein 8; Heat Shock 22kDa Protein 8; E2-Induced Gene 1 Protein; Alpha-Crystallin C Chain; Protein Kinase H11; E2IG1; HSP22;
Function
Displays temperature-dependent chaperone activity.
Biological Process
Cellular response to unfolded protein Source: ARUK-UCL
Positive regulation of aggrephagy Source: ARUK-UCL
Cellular Location
Cytoplasm; Nucleus. Translocates to nuclear foci during heat shock.
Involvement in disease
Neuronopathy, distal hereditary motor, 2A (HMN2A):
A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
Charcot-Marie-Tooth disease 2L (CMT2L):
An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.

Anti-HSPB8 antibodies

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Target: HSPB8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2406
Application*: E, P, WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2405
Application*: E, WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2404
Application*: F, IF, WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-2400
Application*: E, P, WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-2399
Application*: SE, E, WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYH-2398
Application*: WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Rat, Monkey
Clone: CBFYH-2395
Application*: WB, F, IF
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYH-3252
Application*: WB, IH, IF, E
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B6
Application*: E, M
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EC129
Application*: WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A326
Application*: WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: A325
Application*: ICC/IF, ELISA, IHC, WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CB257
Application*: WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 3C12-H11
Application*: ELISA, IF, IHC, WB
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5G3
Application*: WB, E
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: 5D7
Application*: WB, E
Target: HSPB8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3C5
Application*: WB, E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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