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HSPA9

This gene encodes a member of the heat shock protein 70 gene family. The encoded protein is primarily localized to the mitochondria but is also found in the endoplasmic reticulum, plasma membrane and cytoplasmic vesicles. This protein is a heat-shock cognate protein. This protein plays a role in cell proliferation, stress response and maintenance of the mitochondria. A pseudogene of this gene is found on chromosome 2.[provided by RefSeq, May 2010]
Full Name
Heat Shock Protein Family A (Hsp70) Member 9
Function
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (PubMed:26702583).

Regulates erythropoiesis via stabilization of ISC assembly (PubMed:21123823, PubMed:26702583).

May play a role in the control of cell proliferation and cellular aging (By similarity).
Biological Process
Cellular response to unfolded protein Source: GO_Central
Chaperone cofactor-dependent protein refolding Source: GO_Central
Erythrocyte differentiation Source: UniProtKB
Inner mitochondrial membrane organization Source: UniProtKB
Iron-sulfur cluster assembly Source: UniProtKB
Negative regulation of apoptotic process Source: UniProtKB
Negative regulation of erythrocyte differentiation Source: UniProtKB
Negative regulation of hematopoietic stem cell differentiation Source: Ensembl
Negative regulation of hemopoiesis Source: Ensembl
Protein export from nucleus Source: Ensembl
Protein refolding Source: GO_Central
Regulation of erythrocyte differentiation Source: UniProtKB
Cellular Location
Mitochondrion; Nucleolus
Involvement in disease
Anemia, sideroblastic, 4 (SIDBA4):
A form of sideroblastic anemia, a bone marrow disorder defined by the presence of pathologic iron deposits in erythroblast mitochondria. Sideroblastic anemia is characterized by anemia of varying severity, hypochromic peripheral erythrocytes, systemic iron overload secondary to chronic ineffective erythropoiesis, and the presence of bone marrow ringed sideroblasts. Sideroblasts are characterized by iron-loaded mitochondria clustered around the nucleus. SIDBA4 has been reported to be inherited as an autosomal recessive disease, with a pseudodominant pattern of inheritance in some families.
Even-plus syndrome (EVPLS):
An autosomal recessive syndrome characterized by epiphyseal and vertebral dysplasia, prenatal-onset short stature, a distinct craniofacial phenotype with microtia, a flat facial profile with flat nose and triangular nares, cardiac malformations, and additional findings such as anal atresia, hypodontia, aplasia cutis, and others.

Anti-HSPA9 antibodies

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Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Mouse
Clone: S52A-42
Application*: E, IC, IF, IH, P, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat, Dog, Monkey
Clone: 9F8
Application*: F, IC, IF, IH, P, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG3
Specificity: Mouse, Rat, Guinea pig, Hamster, Dog, Human
Clone: JG1
Application*: F, IC, IF, P, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2323
Application*: IF, F
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-2322
Application*: IF, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYH-2321
Application*: WB, IH, IF, F
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYH-2320
Application*: WB, IF
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2319
Application*: IF, F, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2318
Application*: IH, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse
Clone: CBFYH-2317
Application*: IC, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBFYH-2315
Application*: E, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2312
Application*: IH, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: CBFYH-2311
Application*: IC, IF, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBFYH-3242
Application*: IH, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A313
Application*: IF, IHC, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: C. elegans, Human, Mouse, Rat
Clone: S52A-42
Application*: ICC/IF, ELISA, IHC, IP, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBLG1-2307
Application*: WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2305
Application*: WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBLG1-3066
Application*: WB
Target: HSPA9
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D13H4
Application*: WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Mouse, Rat
Clone: A6-A5-B1
Application*: WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Cattle, Cat, Guinea pig, Monkey, Mouse, Pig, Rabbit, Rat, Sheep, Frog
Clone: 4E86
Application*: IH, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Monkey, Rat
Clone: 4A1
Application*: IC/IF, WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10D7
Application*: F
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse, Rat
Clone: 419612
Application*: WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat, Pig, Cattle, Dog, Chicken, Friut fly, Guinea pig, Hamster, Rabbit, Sheep, Frog
Clone: 30A5
Application*: WB
Target: HSPA9
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 10F705
Application*: IH, IP, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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