HOXB4

This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.

HOMEOBOX B4

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Anterior/posterior pattern specification Source: GO_Central
Bone marrow development Source: Ensembl
Cell population proliferation Source: Ensembl
Definitive hemopoiesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hematopoietic stem cell differentiation Source: BHF-UCL
Morphogenesis of an epithelial sheet Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of stem cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell division Source: Ensembl
Spleen development Source: Ensembl

Nucleus