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Mouse Anti-HOXB4 (AA 16-251) Recombinant Antibody (3A2F2) (CBMAB-H2771-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3A2F2
Antibody Isotype
IgG2a
Application
ELISA, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of human HOXB4 expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 16-251

Target

Full Name
HOMEOBOX B4
Introduction
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Intracellular or ectopic expression of this protein expands hematopoietic stem and progenitor cells in vivo and in vitro, making it a potential candidate for therapeutic stem cell expansion.
Entrez Gene ID
3214
UniProt ID
P17483
Alternative Names
Homeobox B4; Homeobox Protein Hox-2.6; Homeobox Protein Hox-2F; Homeo Box B4; HOX2F; Homeobox Protein Hox-B4; Homeo Box 2F; HOX-2.6; HOX2
Function
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Biological Process
Anterior/posterior pattern specification Source: GO_Central
Bone marrow development Source: Ensembl
Cell population proliferation Source: Ensembl
Definitive hemopoiesis Source: Ensembl
Embryonic skeletal system morphogenesis Source: GO_Central
Hematopoietic stem cell differentiation Source: BHF-UCL
Morphogenesis of an epithelial sheet Source: Ensembl
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of stem cell differentiation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Somatic stem cell division Source: Ensembl
Spleen development Source: Ensembl
Cellular Location
Nucleus
More Infomation

Wang, L., Jin, H., Zeng, Y., Tan, Y., Wang, J., Fu, W., ... & Zhou, Z. (2022). HOXB4 Mis-regulation induced by microcystin-LR and correlated with immune infiltration is unfavorable to colorectal cancer prognosis. Frontiers in Oncology, 12, 803493.

Liang, J., Cao, Y., He, M., Li, W., Huang, G., Ma, T., ... & Hu, Y. (2021). AKR1C3 and its transcription factor HOXB4 are promising diagnostic biomarkers for acute myocardial infarction. Frontiers in Cardiovascular Medicine, 8, 694238.

Lei, D., Yang, W. T., & Zheng, P. S. (2021). HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway. Cell Death & Disease, 12(1), 105.

Lin, S., Chen, Q., Zhang, L., Ge, S., Luo, Y., He, W., ... & Zeng, M. (2021). Overexpression of HOXB4 promotes protection of bone marrow mesenchymal stem cells against lipopolysaccharide-induced acute lung injury partially through the activation of Wnt/β-catenin signaling. Journal of Inflammation Research, 14, 3637.

Elcheva, I. A., Wood, T., Chiarolanzio, K., Chim, B., Wong, M., Singh, V., ... & Spiegelman, V. S. (2020). RNA-binding protein IGF2BP1 maintains leukemia stem cell properties by regulating HOXB4, MYB, and ALDH1A1. Leukemia, 34(5), 1354-1363.

Li, N., Gou, J. H., Xiong, J., You, J. J., & Li, Z. Y. (2020). HOXB4 promotes the malignant progression of ovarian cancer via DHDDS. BMC cancer, 20, 1-12.

Dumas, P. Y., Mansier, O., Prouzet-Mauleon, V., Koya, J., Villacreces, A., Brunet De La Grange, P., ... & Lippert, E. (2018). MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasms. BMC cancer, 18, 1-11.

Li, Y., Sun, J., Gao, S., Hu, H., & Xie, P. (2018). HOXB4 knockdown enhances the cytotoxic effect of paclitaxel and cisplatin by downregulating ABC transporters in ovarian cancer cells. Gene, 663, 9-16.

Teichweyde, N., Kasperidus, L., Carotta, S., Kouskoff, V., Lacaud, G., Horn, P. A., ... & Klump, H. (2018). HOXB4 promotes hemogenic endothelium formation without perturbing endothelial cell development. Stem Cell Reports, 10(3), 875-889.

AlKusayer, G. M., Pon, J. R., Peng, B., Klausen, C., Lisonkova, S., Kinloch, M., ... & Bedaiwy, M. A. (2018). HOXB4 immunoreactivity in endometrial tissues from women with or without endometriosis. Reproductive Sciences, 25(6), 950-957.

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For research use only. Not intended for any clinical use.

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