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HDAC10

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Full Name
HDAC10
Function
Polyamine deacetylase (PDAC), which acts preferentially on N8-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954).

Exhibits attenuated catalytic activity toward N1,N8-diacetylspermidine and very low activity, if any, toward N1-acetylspermidine (PubMed:28516954).

Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383).

Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039).

The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954).

May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769).

May play a role in homologous recombination (PubMed:21247901).

May promote DNA mismatch repair (PubMed:26221039).
Biological Process
Chromatin organization Source: UniProtKB
DNA repair Source: UniProtKB-KW
Histone deacetylation Source: UniProtKB
Homologous recombination Source: UniProtKB
Macroautophagy Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Peptidyl-lysine deacetylation Source: UniProtKB
Polyamine deacetylation Source: UniProtKB
Positive regulation of mismatch repair Source: UniProtKB
Protein deacetylation Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Spermidine deacetylation Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus. Excluded from nucleoli.
Involvement in disease
In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752).

Anti-HDAC10 antibodies

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B2
Application*: E, IP
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0826
Application*: F, IH, IP, WB
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0824
Application*: WB, IH, IF
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0823
Application*: WB, IH, F
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0822
Application*: WB, IP
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0821
Application*: WB, F, IP
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0820
Application*: WB, IF, F
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0819
Application*: WB, IF, F
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0818
Application*: IF, P, WB
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0817
Application*: IH, WB
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0816
Application*: F, P, WB
Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B6B8
Application*: E, WB, P, IF, F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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