HAND2

The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq]

HAND2

Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).

Adult heart development Source: BHF-UCL
Angiogenesis Source: UniProtKB-KW
Apoptotic process involved in heart morphogenesis Source: Ensembl
Cardiac neural crest cell development involved in outflow tract morphogenesis Source: BHF-UCL
Cardiac neural crest cell migration involved in outflow tract morphogenesis Source: Ensembl
Cardiac right ventricle formation Source: Ensembl
Cartilage morphogenesis Source: Ensembl
Cell proliferation involved in outflow tract morphogenesis Source: Ensembl
Cellular response to organic cyclic compound Source: Ensembl
Cellular response to retinoic acid Source: Ensembl
Coronary artery morphogenesis Source: Ensembl
Developmental process Source: GO_Central
Embryonic digit morphogenesis Source: Ensembl
Embryonic skeletal system development Source: Ensembl
Heart development Source: GO_Central
Heart looping Source: Ensembl
In utero embryonic development Source: Ensembl
Mesenchymal cell proliferation Source: Ensembl
Negative regulation of cardiac muscle cell apoptotic process Source: BHF-UCL
Negative regulation of DNA binding Source: Ensembl
Negative regulation of DNA-binding transcription factor activity Source: Ensembl
Negative regulation of gene expression Source: BHF-UCL
Negative regulation of osteoblast differentiation Source: Ensembl
Noradrenergic neuron differentiation Source: BHF-UCL
Odontogenesis of dentin-containing tooth Source: Ensembl
Peripheral nervous system neuron development Source: Ensembl
Positive regulation of cardiac muscle hypertrophy Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of gene expression Source: BHF-UCL
Positive regulation of p38MAPK cascade Source: BHF-UCL
Positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process Source: BHF-UCL
Positive regulation of transcription regulatory region DNA binding Source: BHF-UCL
Primary palate development Source: Ensembl
Regulation of secondary heart field cardioblast proliferation Source: BHF-UCL
Regulation of tissue remodeling Source: BHF-UCL
Regulation of transcription by RNA polymerase II Source: GO_Central
Suckling behavior Source: Ensembl
Sympathetic nervous system development Source: Ensembl
Thymus development Source: BHF-UCL
Tongue development Source: Ensembl
Visceral serous pericardium development Source: Ensembl

Nucleus