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GSC

This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]

Full Name

Goosecoid Homeobox

Function

Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).

Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.

Biological Process

Dorsal/ventral neural tube patterning Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forebrain development Source: Ensembl
Gastrulation Source: UniProtKB
Middle ear morphogenesis Source: UniProtKB
Muscle organ morphogenesis Source: Ensembl
Negative regulation of Wnt signaling pathway Source: Ensembl
Neural crest cell fate specification Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl

Cellular Location

Nucleus

Involvement in disease

Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS):
An autosomal recessive developmental disorder with features of a first and second branchial arch syndrome, and with unique rhizomelic skeletal anomalies. Craniofacial abnormalities can lead to conductive hearing loss, respiratory insufficiency, and feeding difficulties. Skeletal features include bilateral humeral hypoplasia, humeroscapular synostosis, pelvic abnormalities, and proximal defects of the femora. Affected individuals may also have some features of a neurocristopathy or abnormal mesoderm development, such as urogenital anomalies, that are distinct from other branchial arch syndromes.

Anti-GSC antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

GSC Matched Antibody Pair (503) (APMAB-503LY)

SDS

Target: GSC

Specificity: Human

Mouse Anti-GSC Recombinant Antibody (CBLG1-1824) (CBMAB-G5126-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1824

Application*: E, WB

Mouse Anti-GSC Recombinant Antibody (CBLG1-1823) (CBMAB-G5125-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBLG1-1823

Application*: SE, E, WB

Mouse Anti-GSC Recombinant Antibody (CBLG1-2982) (CBMAB-G5124-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBLG1-2982

Application*: WB

Mouse Anti-GSC Recombinant Antibody (CBLG1-2981) (CBMAB-G5123-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2981

Application*: WB

Mouse Anti-GSC Recombinant Antibody (4F11) (CBMAB-G5120-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4F11

Application*: IF, WB

Mouse Anti-GSC Recombinant Antibody (4C5D5) (CBMAB-G5118-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4C5D5

Application*: E, F

Mouse Anti-GSC Recombinant Antibody (4C5D10) (CBMAB-G5117-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4C5D10

Application*: E, WB

Mouse Anti-GSC Recombinant Antibody (V2-86123) (CBMAB-G5116-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: V2-86123

Application*: E, IF, WB

Mouse Anti-GSC Recombinant Antibody (3D11) (CBMAB-G5112-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 3D11

Application*: E, WB

Mouse Anti-GSC Recombinant Antibody (2C1) (CBMAB-G5110-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 2C1

Application*: E, WB

Mouse Anti-GSC Recombinant Antibody (1D7) (CBMAB-G5107-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D7

Application*: F

Mouse Anti-GSC Recombinant Antibody (1C2) (CBMAB-G5106-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 1C2

Application*: E, IH, WB

Mouse Anti-GSC Recombinant Antibody (14i161) (CBMAB-G5105-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 14i161

Application*: E, WB

Mouse Anti-GSC Recombinant Antibody (14i160) (CBMAB-G5104-LY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 14i160

Application*: E, F

Mouse Anti-GSC Recombinant Antibody (CBFYH-0502) (CBMAB-H1372-FY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-0502

Application*: E, EC, WB

Mouse Anti-GSC (AA 87-186) Recombinant Antibody (CBFYH-0501) (CBMAB-H1371-FY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-0501

Application*: E, P, WB

Mouse Anti-GSC (AA 78-186) Recombinant Antibody (CBFYH-0500) (CBMAB-H1370-FY)

SDS

Target: GSC

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYH-0500

Application*: E, P, WB

Mouse Anti-GSC (AA 191-257) Recombinant Antibody (CBFYH-2853) (CBMAB-H1369-FY)

SDS

Target: GSC

Host: Mouse

Specificity: Human

Clone: CBFYH-2853

Application*: E, F, IH, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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