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Mouse Anti-GSC Recombinant Antibody (4C5D10) (CBMAB-G5117-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4C5D10
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
The immunogen corresponding to a region within amino acids 191 and 257 of human GSC expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.5% protein stabilizer
Preservative
0.05% sodium azide
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Goosecoid Homeobox
Introduction
This gene encodes a member of the bicoid subfamily of the paired (PRD) homeobox family of proteins. The encoded protein acts as a transcription factor and may be autoregulatory. A similar protein in mice plays a role in craniofacial and rib cage development during embryogenesis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
145258
UniProt ID
P56915
Alternative Names
Goosecoid Homeobox; Homeobox Protein Goosecoid; SAMS;
Function
Regulates chordin (CHRD). May play a role in spatial programing within discrete embryonic fields or lineage compartments during organogenesis. In concert with NKX3-2, plays a role in defining the structural components of the middle ear; required for the development of the entire tympanic ring (By similarity).

Probably involved in the regulatory networks that define neural crest cell fate specification and determine mesoderm cell lineages in mammals.
Biological Process
Dorsal/ventral neural tube patterning Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Forebrain development Source: Ensembl
Gastrulation Source: UniProtKB
Middle ear morphogenesis Source: UniProtKB
Muscle organ morphogenesis Source: Ensembl
Negative regulation of Wnt signaling pathway Source: Ensembl
Neural crest cell fate specification Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction involved in regulation of gene expression Source: Ensembl
Cellular Location
Nucleus
Involvement in disease
Short stature, auditory canal atresia, mandibular hypoplasia, skeletal abnormalities (SAMS):
An autosomal recessive developmental disorder with features of a first and second branchial arch syndrome, and with unique rhizomelic skeletal anomalies. Craniofacial abnormalities can lead to conductive hearing loss, respiratory insufficiency, and feeding difficulties. Skeletal features include bilateral humeral hypoplasia, humeroscapular synostosis, pelvic abnormalities, and proximal defects of the femora. Affected individuals may also have some features of a neurocristopathy or abnormal mesoderm development, such as urogenital anomalies, that are distinct from other branchial arch syndromes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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