GOSR1

This gene encodes a trafficking membrane protein which transports proteins among the endoplasmic reticulum and the Golgi and between Golgi compartments. This protein is considered an essential component of the Golgi SNAP receptor (SNARE) complex. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

golgi SNAP receptor complex member 1

Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi.

Endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
Intra-Golgi vesicle-mediated transport Source: ProtInc
Protein transport Source: UniProtKB-KW
Regulation of vesicle targeting, to, from or within Golgi Source: GO_Central
Retrograde transport, endosome to Golgi Source: HGNC-UCL
Vesicle fusion Source: GO_Central

Golgi apparatus membrane. Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network (By similarity). Enriched on vesicular components at the terminal rims of the Golgi. Found in Golgi microtubules at low temperature (15 degrees Celsius).

Cytoplasmic: 2-229
Helical: 230-250