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GLO1

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]

Full Name

Glyoxalase I

Function

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.

Biological Process

Carbohydrate metabolic process Source: ProtInc
Glutathione metabolic process Source: Ensembl
Methylglyoxal metabolic process Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Osteoclast differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: Ensembl

Cellular Location

Cytosol; Extracellular exosome; Nucleoplasm; Plasma membrane; Cytoplasm

PTM

Glutathionylation at Cys-139 inhibits enzyme activity.
Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.
Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B.

Anti-GLO1 antibodies

Mouse Anti-GLO1 Recombinant Antibody (14) (CBMAB-G3809-LY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 14

Application*: WB

Mouse Anti-GLO1 Recombinant Antibody (4C12) (CBMAB-G3812-LY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4C12

Application*: E

Mouse Anti-GLO1 Recombinant Antibody (CBLG1-1281) (CBMAB-G3823-LY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1281

Application*: E, P, WB

Mouse Anti-GLO1 Recombinant Antibody (266) (CBMAB-G3810-LY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 266

Application*: WB

Rabbit Anti-GLO1 Recombinant Antibody (43) (CBMAB-G3811-LY)

SDS

Target: GLO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: 43

Application*: E

Mouse Anti-GLO1 Recombinant Antibody (552) (CBMAB-G3813-LY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Rat

Clone: 552

Application*: WB

Rat Anti-GLO1 Recombinant Antibody (6F10) (CBMAB-G3814-LY)

SDS

Target: GLO1

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse, Human

Clone: 6F10

Application*: WB

Mouse Anti-GLO1 Recombinant Antibody (CBLG1-1277) (CBMAB-G3819-LY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-1277

Application*: E, WB

Rabbit Anti-GLO1 Recombinant Antibody (CBLG1-1283) (CBMAB-G3825-LY)

SDS

Target: GLO1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBLG1-1283

Application*: E

Mouse Anti-GLO1 Antibody (6BA21) (CBMAB-1286CQ)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6BA21

Application*: IH, M, WB

Mouse Anti-GLO1 Antibody (6BA22) (CBMAB-1287CQ)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 6BA22

Application*: E, P, IH, M, WB

Mouse Anti-GLO1 Antibody (6BA23) (CBMAB-1288CQ)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6BA23

Application*: E, IH, WB

Recombinant Mouse Anti-GLO1 Antibody (CBHb366) (CBMAB-Hb518-LY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBHb366

Application*: WB

Mouse Anti-GLO1 Recombinant Antibody (12C1E2F) (CBMAB-H1257-FY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 12C1E2F

Application*: F

Mouse Anti-GLO1 (AA 83-184) Recombinant Antibody (CBFYH-0386) (CBMAB-H1259-FY)

SDS

Target: GLO1

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYH-0386

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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