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GLO1

The enzyme encoded by this gene is responsible for the catalysis and formation of S-lactoyl-glutathione from methylglyoxal condensation and reduced glutatione. Glyoxalase I is linked to HLA and is localized to 6p21.3-p21.1, between HLA and the centromere. [provided by RefSeq, Jul 2008]
Full Name
Glyoxalase I
Function
Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis.
Biological Process
Carbohydrate metabolic process Source: ProtInc
Glutathione metabolic process Source: Ensembl
Methylglyoxal metabolic process Source: Ensembl
Negative regulation of apoptotic process Source: UniProtKB
Osteoclast differentiation Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: Ensembl
Cellular Location
Cytosol; Extracellular exosome; Nucleoplasm; Plasma membrane; Cytoplasm
PTM
Glutathionylation at Cys-139 inhibits enzyme activity.
Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B.
Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B.

Anti-GLO1 antibodies

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Recombinant Mouse Anti-GLO1 Antibody (CBHb366) (CBMAB-Hb518-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb366
Application*: WB

Rabbit Anti-GLO1 Recombinant Antibody (CBLG1-1283) (CBMAB-G3825-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBLG1-1283
Application*: E

Mouse Anti-GLO1 Recombinant Antibody (CBLG1-1281) (CBMAB-G3823-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1281
Application*: E, P, WB

Mouse Anti-GLO1 Recombinant Antibody (CBLG1-1277) (CBMAB-G3819-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-1277
Application*: E, WB

Rat Anti-GLO1 Recombinant Antibody (6F10) (CBMAB-G3814-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse, Human
Clone: 6F10
Application*: WB

Mouse Anti-GLO1 Recombinant Antibody (552) (CBMAB-G3813-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 552
Application*: WB

Mouse Anti-GLO1 Recombinant Antibody (4C12) (CBMAB-G3812-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4C12
Application*: E

Rabbit Anti-GLO1 Recombinant Antibody (43) (CBMAB-G3811-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 43
Application*: E

Mouse Anti-GLO1 Recombinant Antibody (266) (CBMAB-G3810-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 266
Application*: WB

Mouse Anti-GLO1 Recombinant Antibody (14) (CBMAB-G3809-LY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 14
Application*: WB

Mouse Anti-GLO1 (AA 83-184) Recombinant Antibody (CBFYH-0386) (CBMAB-H1259-FY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0386
Application*: E, WB

Mouse Anti-GLO1 Recombinant Antibody (12C1E2F) (CBMAB-H1257-FY)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 12C1E2F
Application*: F

Mouse Anti-GLO1 Antibody (6BA23) (CBMAB-1288CQ)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6BA23
Application*: E, IH, WB

Mouse Anti-GLO1 Antibody (6BA22) (CBMAB-1287CQ)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6BA22
Application*: E, P, IH, M, WB

Mouse Anti-GLO1 Antibody (6BA21) (CBMAB-1286CQ)

Datasheet Datasheet SDS SDS
Target: GLO1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6BA21
Application*: IH, M, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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