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GLA

This gene encodes a homodimeric glycoprotein that hydrolyses the terminal alpha-galactosyl moieties from glycolipids and glycoproteins. This enzyme predominantly hydrolyzes ceramide trihexoside, and it can catalyze the hydrolysis of melibiose into galactose and glucose. A variety of mutations in this gene affect the synthesis, processing, and stability of this enzyme, which causes Fabry disease, a rare lysosomal storage disorder that results from a failure to catabolize alpha-D-galactosyl glycolipid moieties. [provided by RefSeq, Jul 2008]

Full Name

Galactosidase Alpha

Function

Catalyzes the hydrolysis of glycosphingolipids and participates in their degradation in the lysosome.

Biological Process

Glycoside catabolic process Source: GO_Central
Glycosphingolipid catabolic process Source: UniProtKB
Glycosylceramide catabolic process Source: UniProtKB
Negative regulation of nitric oxide biosynthetic process Source: UniProtKB
Negative regulation of nitric-oxide synthase activity Source: UniProtKB
Oligosaccharide metabolic process Source: UniProtKB

Cellular Location

Lysosome

Involvement in disease

Fabry disease (FD):
Rare X-linked sphingolipidosis disease where glycolipid accumulates in many tissues. The disease consists of an inborn error of glycosphingolipid catabolism. FD patients show systemic accumulation of globotriaosylceramide (Gb3) and related glycosphingolipids in the plasma and cellular lysosomes throughout the body. Clinical recognition in males results from characteristic skin lesions (angiokeratomas) over the lower trunk. Patients may show ocular deposits, febrile episodes, and burning pain in the extremities. Death results from renal failure, cardiac or cerebral complications of hypertension or other vascular disease. Heterozygous females may exhibit the disorder in an attenuated form, they are more likely to show corneal opacities.

Anti-GLA antibodies

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Mouse Anti-GLA Recombinant Antibody (CF184) (CBMAB-FT452LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CF184

Application*: ELISA, WB, IHC, IF

Rabbit Anti-GLA Recombinant Antibody (CBLG1-2776) (CBMAB-G3648-LY)

SDS

Target: GLA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLG1-2776

Application*: WB

Mouse Anti-GLA Recombinant Antibody (407) (CBMAB-AP2540LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 407

Application*: ELISA, IF, IHC, WB

Mouse Anti-GLA Recombinant Antibody (C2) (CBMAB-AP2539LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: C2

Application*: ICC, IHC, IP, WB

Mouse Anti-GLA Recombinant Antibody (C6) (CBMAB-AP2538LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: C6

Application*: ICC, IHC, IP, WB

Mouse Anti-GLA Monoclonal Antibody (CBFYH-2974) (CBMAB-H1241-FY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYH-2974

Application*: E, IF, IH, WB, IR

Rabbit Anti-GLA Recombinant Antibody (201) (CBMAB-A4425-YC)

SDS

Target: GLA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 201

Application*: WB

Mouse Anti-GLA Recombinant Antibody (CBLG1-1256) (CBMAB-G3658-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1256

Application*: E, P, WB

Mouse Anti-GLA Recombinant Antibody (CBLG1-1253) (CBMAB-G3655-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1253

Application*: E, WB

Mouse Anti-GLA Recombinant Antibody (CBLG1-1251) (CBMAB-G3653-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1251

Application*: E

Mouse Anti-GLA Recombinant Antibody (CBLG1-1250) (CBMAB-G3652-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1250

Application*: IC, C/P, E (IA), WB

Mouse Anti-GLA Recombinant Antibody (CBLG1-1247) (CBMAB-G3649-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1247

Application*: WB

Mouse Anti-GLA Recombinant Antibody (2H7G10) (CBMAB-G3646-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 2H7G10

Application*: E

Mouse Anti-GLA Recombinant Antibody (13j37) (CBMAB-G3644-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: 13j37

Application*: E, IC, IH, WB

Rabbit Anti-GLA Recombinant Antibody (1) (CBMAB-G3643-LY)

SDS

Target: GLA

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 1

Application*: E, WB

Mouse Anti-GLA Recombinant Antibody (CBLG1-120) (CBMAB-G0508-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-120

Application*: E, IC, WB

Mouse Anti-GLA Recombinant Antibody (CBLG1-119) (CBMAB-G0507-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-119

Application*: WB

Mouse Anti-GLA Recombinant Antibody (M3B) (CBMAB-G0505-LY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: M3B

Application*: IP

Mouse Anti-GLA (AA 1-429) Recombinant Antibody (CBFYH-0371) (CBMAB-H1242-FY)

SDS

Target: GLA

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYH-0371

Application*: E

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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