GBP5

This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]

Guanylate Binding Protein 5

As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501).

Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).

Cellular response to interferon-gamma Source: UniProtKB
Inflammatory response Source: UniProtKB-KW
Positive regulation of cytokine production involved in inflammatory response Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of interleukin-18 production Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
Protein homotetramerization Source: UniProtKB
Protein localization to Golgi apparatus Source: UniProtKB

Cytoplasm; Golgi apparatus membrane

Isoprenylation is required for proper subcellular location.