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Mouse Anti-GBP5 Recombinant Antibody (CBLG1-2667) (CBMAB-G2446-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-2667
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human GBP5 (NP_443174) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% NaN3
Concentration
1 mg/mL
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Guanylate Binding Protein 5
Introduction
This gene belongs to the TRAFAC class dynamin-like GTPase superfamily. The encoded protein acts as an activator of NLRP3 inflammasome assembly and has a role in innate immunity and inflammation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Entrez Gene ID
115362
UniProt ID
Q96PP8
Alternative Names
Guanylate Binding Protein 5; Guanine Nucleotide-Binding Protein 5; GTP-Binding Protein 5; GBP-TA Antigen; GBP-5; Guanylate-Binding Protein 5; EC 3.6.5.-;
Function
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents (PubMed:22461501).

Hydrolyzes GTP, but in contrast to other family members, does not produce GMP (PubMed:20180847).
Biological Process
Cellular response to interferon-gamma Source: UniProtKB
Inflammatory response Source: UniProtKB-KW
Positive regulation of cytokine production involved in inflammatory response Source: UniProtKB
Positive regulation of innate immune response Source: UniProtKB
Positive regulation of interleukin-18 production Source: UniProtKB
Positive regulation of interleukin-1 beta production Source: UniProtKB
Positive regulation of NLRP3 inflammasome complex assembly Source: UniProtKB
Protein homotetramerization Source: UniProtKB
Protein localization to Golgi apparatus Source: UniProtKB
Cellular Location
Cytoplasm; Golgi apparatus membrane
PTM
Isoprenylation is required for proper subcellular location.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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