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FZD5

Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD5 protein is believed to be the receptor for the Wnt5A ligand.
Full Name
frizzled class receptor 5
Function
Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549).

Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity).

In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549).

Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity).

A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity).
Biological Process
Angiogenesis Source: Ensembl
Anterior/posterior axis specification, embryo Source: BHF-UCL
Apoptotic process involved in morphogenesis Source: Ensembl
Branching involved in labyrinthine layer morphogenesis Source: Ensembl
Canonical Wnt signaling pathway Source: BHF-UCL
Cell maturation Source: Ensembl
Cellular response to molecule of bacterial origin Source: BHF-UCL
Chorionic trophoblast cell differentiation Source: Ensembl
Embryonic axis specification Source: BHF-UCL
Embryonic camera-type eye morphogenesis Source: Ensembl
Labyrinthine layer blood vessel development Source: Ensembl
Negative regulation of cell population proliferation Source: Ensembl
Neuron differentiation Source: UniProtKB
Positive regulation of interferon-gamma production Source: BHF-UCL
Positive regulation of interleukin-1 beta production Source: ARUK-UCL
Positive regulation of JUN kinase activity Source: Ensembl
Positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
Positive regulation of T cell cytokine production Source: CACAO
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tumor necrosis factor production Source: ARUK-UCL
Post-embryonic camera-type eye development Source: Ensembl
Regulation of autophagy of mitochondrion Source: ParkinsonsUK-UCL
Regulation of bicellular tight junction assembly Source: Ensembl
Regulation of chorionic trophoblast cell proliferation Source: Ensembl
Spemann organizer formation Source: BHF-UCL
Synapse assembly Source: ParkinsonsUK-UCL
Syncytiotrophoblast cell differentiation involved in labyrinthine layer development Source: Ensembl
T cell differentiation in thymus Source: Ensembl
Cellular Location
Golgi apparatus membrane; Cell membrane; Synapse; Perikaryon; Dendrite; Axon. Localized at the plasma membrane and also found at the Golgi.
Topology
Extracellular: 27-238
Helical: 239-259
Cytoplasmic: 260-270
Helical: 271-291
Extracellular: 292-315
Helical: 316-336
Cytoplasmic: 337-358
Helical: 359-379
Extracellular: 380-402
Helical: 403-423
Cytoplasmic: 424-449
Helical: 450-470
Extracellular: 471-500
Helical: 501-521
Cytoplasmic: 522-585
PTM
Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome.

Anti-FZD5 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: FZD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6A3
Application*: WB, E
Target: FZD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-1615
Application*: E, F, WB
Target: FZD5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3268
Application*: E, IP, WB
Target: FZD5
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-1820
Application*: WB, IP, F, E
Target: FZD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2087
Application*: WB, IP
Target: FZD5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-0990
Application*: F, WB
Target: FZD5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-2374
Application*: WB, F, IC
Target: FZD5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-0991
Application*: WB
Target: FZD5
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1256
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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