FOXD3

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1.

Full Name

forkhead box D3

Function

Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.

Biological Process

Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
In utero embryonic development Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Involvement in disease

Autoimmune disease 1 (AIS1):
An autoimmune disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis).

Anti-FOXD3 antibodies

Rabbit Anti-FOXD3 Monoclonal Antibody (B.81.8) (CBMAB-1276-YC)

Datasheet

SDS

Target: FOXD3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: B.81.8

Application*: WB

Mouse Anti-FOXD3 Monoclonal Antibody (5G9) (CBMAB-1275-YC)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Monkey

Clone: 5G9

Application*: E, WB

Mouse Anti-FOXD3 Recombinant Antibody (2A11G9, 2A11C2) (CBMAB-AO479LY)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 2A11G9, 2A11C2

Application*: WB, IHC

Mouse Anti-FOXD3 Recombinant Antibody (5G9) (CBMAB-AO477LY)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5G9

Application*: WB, IHC

Rabbit Anti-FOXD3 Recombinant Antibody (D20A9) (CBMAB-CP0742-LY)

Datasheet

SDS

Target: FOXD3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: D20A9

Application*: WB

Mouse Anti-FOXD3 Recombinant Antibody (3D11-E3-G3) (CBMAB-Z0307-LY)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Monkey

Clone: 3D11-E3-G3

Application*: WB, IH

Mouse Anti-FOXD3 Recombinant Antibody (CBXF-1602) (CBMAB-F4127-CQ)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse

Clone: CBXF-1602

Application*: E, WB

Mouse Anti-FOXD3 Recombinant Antibody (CBXF-1603) (CBMAB-F4126-CQ)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Monkey, Mouse

Clone: CBXF-1603

Application*: E, IH, WB

Mouse Anti-FOXD3 Recombinant Antibody (CBXF-1773) (CBMAB-F3308-CQ)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: CBXF-1773

Application*: WB, IP, IF, P, E

Rat Anti-FOXD3 Recombinant Antibody (CBXF-2660) (CBMAB-F3075-CQ)

Datasheet

SDS

Target: FOXD3

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBXF-2660

Application*: IC

Rabbit Anti-FOXD3 Recombinant Antibody (CBXF-2251) (CBMAB-F1991-CQ)

Datasheet

SDS

Target: FOXD3

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBXF-2251

Application*: WB

Mouse Anti-FOXD3 Recombinant Antibody (CBXF-0837) (CBMAB-F1735-CQ)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Monkey

Clone: CBXF-0837

Application*: E, WB

Mouse Anti-FOXD3 Recombinant Antibody (CBXF-3736) (CBMAB-F1278-CQ)

Datasheet

SDS

Target: FOXD3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse, Monkey

Clone: CBXF-3736

Application*: E, WB, P, IF, F

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)