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Rabbit Anti-FOXD3 Recombinant Antibody (D20A9) (CBMAB-CP0742-LY)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
D20A9
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues at the C-terminus of human FoxD3.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
forkhead box D3
Introduction
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
Entrez Gene ID
27022
UniProt ID
Q9UJU5
Alternative Names
Forkhead Box D3; HNF3/FH Transcription Factor Genesis; HFH2; Forkhead Box Protein D3; Genesis; VAMAS2; AIS1;
Function
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Biological Process
Anatomical structure morphogenesis Source: GO_Central
Cell differentiation Source: GO_Central
In utero embryonic development Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Involvement in disease
Autoimmune disease 1 (AIS1):
An autoimmune disorder characterized by the association of vitiligo with autoimmune thyroiditis (Hashimoto thyroiditis).
More Infomation

Hu, J., Pan, J., Luo, Z., Duan, Q., & Wang, D. (2021). Long non-coding RNA FOXD3-AS1 silencing exerts tumor suppressive effects in nasopharyngeal carcinoma by downregulating FOXD3 expression via microRNA-185-3p upregulation. Cancer gene therapy, 28(6), 602-618.

Puri, D., Koschorz, B., Engist, B., Onishi‐Seebacher, M., Ryan, D., Soujanya, M., & Montavon, T. (2021). Foxd3 controls heterochromatin‐mediated repression of repeat elements and 2‐cell state transcription. EMBO reports, 22(12), e53180.

Rosenbaum, S. R., Knecht, M., Mollaee, M., Zhong, Z., Erkes, D. A., McCue, P. A., ... & Aplin, A. E. (2020). FOXD3 regulates VISTA expression in melanoma. Cell reports, 30(2), 510-524.

Lu, Y., Han, Y., He, J., Zhou, B., Fang, P., & Li, X. (2020). LncRNA FOXD3-AS1 knockdown protects against cerebral ischemia/reperfusion injury via miR-765/BCL2L13 axis. Biomedicine & pharmacotherapy, 132, 110778.

Chen, X., Gao, J., Yu, Y., Zhao, Z., & Pan, Y. (2019). LncRNA FOXD3-AS1 promotes proliferation, invasion and migration of cutaneous malignant melanoma via regulating miR-325/MAP3K2. Biomedicine & Pharmacotherapy, 120, 109438.

Tong, G., Wang, Y., Xu, C., Xu, Y., Ye, X., Zhou, L., ... & Huang, J. (2019). Long non-coding RNA FOXD3-AS1 aggravates ischemia/reperfusion injury of cardiomyocytes through promoting autophagy. American Journal of Translational Research, 11(9), 5634.

Guan, Y., Bhandari, A., Xia, E., Yang, F., Xiang, J., & Wang, O. (2019). lncRNA FOXD3‐AS1 is associated with clinical progression and regulates cell migration and invasion in breast cancer. Cell Biochemistry and Function, 37(4), 239-244.

Wu, Q., Shi, M., Meng, W., Wang, Y., Hui, P., & Ma, J. (2019). Long noncoding RNA FOXD3‐AS1 promotes colon adenocarcinoma progression and functions as a competing endogenous RNA to regulate SIRT1 by sponging miR‐135a‐5p. Journal of Cellular Physiology, 234(12), 21889-21902.

Lukoseviciute, M., Gavriouchkina, D., Williams, R. M., Hochgreb-Hagele, T., Senanayake, U., Chong-Morrison, V., ... & Sauka-Spengler, T. (2018). From pioneer to repressor: bimodal foxd3 activity dynamically remodels neural crest regulatory landscape in vivo. Developmental cell, 47(5), 608-628.

Zhao, X., Li, D., Huang, D., Song, H., Mei, H., Fang, E., ... & Tong, Q. (2018). Risk-associated long noncoding RNA FOXD3-AS1 inhibits neuroblastoma progression by repressing PARP1-mediated activation of CTCF. Molecular Therapy, 26(3), 755-773.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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