FLOT1

This gene encodes an protein that localizes to the caveolae, which are small domains on the inner cell membranes. This protein plays a role in vesicle trafficking and cell morphology. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Flotillin 1

May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles.

Axonogenesis Source: Ensembl
Cellular response to exogenous dsRNA Source: UniProtKB
dsRNA transport Source: UniProtKB
Extracellular matrix disassembly Source: UniProtKB
Membrane raft assembly Source: UniProtKB
Plasma membrane raft assembly Source: UniProtKB
Positive regulation of cell adhesion molecule production Source: UniProtKB
Positive regulation of cell-cell adhesion mediated by cadherin Source: UniProtKB
Positive regulation of cell junction assembly Source: UniProtKB
Positive regulation of cytokine production Source: UniProtKB
Positive regulation of endocytosis Source: UniProtKB
Positive regulation of heterotypic cell-cell adhesion Source: UniProtKB
Positive regulation of interferon-beta production Source: UniProtKB
Positive regulation of myoblast fusion Source: UniProtKB
Positive regulation of NF-kappaB transcription factor activity Source: ARUK-UCL
Positive regulation of protein binding Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB
Positive regulation of skeletal muscle tissue development Source: UniProtKB
Positive regulation of synaptic transmission, dopaminergic Source: UniProtKB
Positive regulation of toll-like receptor 3 signaling pathway Source: UniProtKB
Protein kinase C signaling Source: UniProtKB
Protein localization to membrane raft Source: UniProtKB
Protein localization to plasma membrane Source: UniProtKB
Protein stabilization Source: UniProtKB
Regulation of neurotransmitter uptake Source: SynGO
Regulation of receptor internalization Source: UniProtKB
Regulation of Rho protein signal transduction Source: Ensembl
Response to endoplasmic reticulum stress Source: UniProtKB

Endosome; Cell membrane; Caveola; Melanosome; Membrane raft. Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Membrane-associated protein of caveola (By similarity).