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ESR2

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]

Full Name

Estrogen Receptor 2

Research Area

Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).

Isoform 2:
Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.

Biological Process

Cell-cell signaling Source: ProtInc
Cellular response to estradiol stimulus Source: CAFA
Intracellular estrogen receptor signaling pathway Source: CAFA
Intracellular steroid hormone receptor signaling pathway Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: CAFA
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Nucleus

Involvement in disease

Ovarian dysgenesis 8 (ODG8):
A form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.

PTM

Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.

Anti-ESR2 antibodies

Mouse Anti-ESR2 Recombinant Antibody (CBFYE-1295) (CBMAB-E1890-FY)

SDS

Target: ESR2

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBFYE-1295

Application*: WB, IP, IF, P, E

Mouse Anti-ESR2 Monoclonal Antibody (ERb455) (CBMAB-1217-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse, Rat, Sheep, Horse, Monkey

Clone: ERb455

Application*: F, IC, IF, P, WB

Mouse Anti-ESR2 Monoclonal Antibody (14C8) (CBMAB-1215-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human, Mouse, Monkey, Baboon

Clone: 14C8

Application*: CI, F, IC, IF, C, P, WB

Mouse Anti-ESR2 Recombinant Antibody (CBFYE-1294) (CBMAB-E1889-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CBFYE-1294

Application*: E, WB

Mouse Anti-ESR2 (AA 162-476) Recombinant Antibody (CBFYE-1293) (CBMAB-E1888-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYE-1293

Application*: WB, IP

Mouse Anti-ESR2 Recombinant Antibody (CBFYE-1292) (CBMAB-E1886-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYE-1292

Application*: E, WB, IC, IH

Mouse Anti-ESR2 (AA 22-121) Recombinant Antibody (CBFYE-1291) (CBMAB-E1885-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: CBFYE-1291

Application*: E, IF, WB

Mouse Anti-ESR2 (AA 1-153) Recombinant Antibody (CBFYE-1290) (CBMAB-E1883-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBFYE-1290

Application*: P, WB

Mouse Anti-ESR2 Recombinant Antibody (CBFYE-1289) (CBMAB-E1882-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYE-1289

Application*: E, IC, IF, P, IP, WB

Mouse Anti-ESR2 Recombinant Antibody (CBFYE-1288) (CBMAB-E1880-FY)

SDS

Target: ESR2

Host: Mouse

Specificity: Human

Clone: CBFYE-1288

Application*: WB, IC, P, C, E

Mouse Anti-ESR2 (C-terminus) Recombinant Antibody (CBFYE-1287) (CBMAB-E1878-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1287

Application*: P

Mouse Anti-ESR2 (C-terminus) Recombinant Antibody (CBFYE-1286) (CBMAB-E1877-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1286

Application*: P, WB

Mouse Anti-ESR2 (C-terminus) Recombinant Antibody (CBFYE-1285) (CBMAB-E1876-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-1285

Application*: IH

Rabbit Anti-ESR2 (AA 63-82) Recombinant Antibody (CBFYE-1284) (CBMAB-E1875-FY)

SDS

Target: ESR2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYE-1284

Application*: IP, WB

Mouse Anti-ESR2 (AA 1-318) Recombinant Antibody (CBFYE-0117) (CBMAB-E0237-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYE-0117

Application*: WB, F, IC, MC

Mouse Anti-ESR2 (C-terminus) Recombinant Antibody (PPG5-10) (CBMAB-E1887-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: PPG5-10

Application*: P, C

Mouse Anti-ESR2 (C-terminus) Recombinant Antibody (NR3Gb-1) (CBMAB-E0358-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Monkey, Mouse, Rat, Pig, Horse, Sheep

Clone: NR3Gb-1

Application*: WB, IH, F, IF

Mouse Anti-ESR2 (C-terminus) Recombinant Antibody (ESR2/686) (CBMAB-E0319-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: ESR2/686

Application*: WB, F, P, IF

Mouse Anti-ESR2 (AA 1-153) Recombinant Antibody (7B10.7) (CBMAB-E1884-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7B10.7

Application*: IP, WB, CI

Mouse Anti-ESR2 (AA 369-397) Recombinant Antibody (555CT18.5.5) (CBMAB-E1881-FY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 555CT18.5.5

Application*: WB, E

Mouse Anti-ESR2 Monoclonal Antibody (6A12) (CBMAB-1188-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 6A12

Application*: IC, IF, IH, CI, WB

Mouse Anti-ESR2 Monoclonal Antibody (Y28C) (CBMAB-1187-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Rat, Monkey, Horse, Pig, Sheep

Clone: Y28C

Application*: F, IC, IF, P, WB

Mouse Anti-ESR2 Antibody (CWK-F12) (CBMAB-1212CQ)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse, Pig, Rat

Clone: CWK-F12

Application*: CI, E, P, B, IF, IH, IP, WB

Rabbit Anti-ESR2 Recombinant Antibody (EG1148) (CBMAB-EN1373-LY)

SDS

Target: ESR2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1148

Application*: WB: 1:500~1:1000 ELISA: 1:10000

Mouse Anti-ESR2 Recombinant Antibody (336) (CBMAB-AP2152LY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 336

Application*: ELISA, WB

Mouse Anti-ESR2 Recombinant Antibody (ESR2/686) (CBMAB-AP2151LY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: ESR2/686

Application*: FC, IF, IHC, WB

Mouse Anti-ESR2 Recombinant Antibody (ERb455) (CBMAB-AP2150LY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Horse, Sheep, Human, Monkey, Mouse, Pig, Rat

Clone: ERb455

Application*: FC, IF, IHC, WB

Mouse Anti-ESR2 Recombinant Antibody (CF155) (CBMAB-FT331LY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: CF155

Application*: ELISA, WB

Mouse Anti-ESR2 Recombinant Antibody (3F3) (CBMAB-A2719-LY)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 3F3

Application*: WB, E

Recombinant Mouse Anti-ESR2 Recombinant Antibody (57/3) (CBMAB-XB0432-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 57/3

Application*: IH, IF, WB

Recombinant Mouse Anti-ESR2 Recombinant Antibody (2H9) (CBMAB-XB0431-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse, Human

Clone: 2H9

Application*: E, IF, WB

Recombinant Mouse Anti-ESR2 Recombinant Antibody (2D7) (CBMAB-XB0430-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse, Human

Clone: 2D7

Application*: E, IH, IF, WB

Recombinant Mouse Anti-ESR2 Recombinant Antibody (2B5) (CBMAB-XB0429-YC)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Mouse

Clone: 2B5

Application*: E, IF, WB

Mouse Anti-ESR2 Recombinant Antibody (PPG5/10) (CBMAB-O0168-CQ)

SDS

Target: ESR2

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: PPG5/10

Application*: IF, IH

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

Online Inquiry