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Mouse Anti-ESR2 (C-terminus) Recombinant Antibody (ESR2/686) (CBMAB-E0319-FY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
ESR2/686
Antibody Isotype
IgG2a
Application
WB, FC, IHC-P, IF

Basic Information

Immunogen
C-terminus fragment of recombinant human estrogen receptor beta protein
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
C-terminus

Target

Full Name
Estrogen Receptor 2
Introduction
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
Entrez Gene ID
2100
UniProt ID
Q92731
Alternative Names
Estrogen Receptor 2; Nuclear Receptor Subfamily 3 Group A Member 2; Oestrogen Receptor Beta; Estrogen Receptor Beta; ER-BETA; ESTRB; NR3A2
Research Area
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560).

Isoform 2:
Lacks ligand binding ability and has no or only very low ERE binding activity resulting in the loss of ligand-dependent transactivation ability.
Biological Process
Cell-cell signaling Source: ProtInc
Cellular response to estradiol stimulus Source: CAFA
Intracellular estrogen receptor signaling pathway Source: CAFA
Intracellular steroid hormone receptor signaling pathway Source: GO_Central
Negative regulation of cell growth Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: UniProtKB
Positive regulation of transcription, DNA-templated Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: CAFA
Regulation of transcription, DNA-templated Source: UniProtKB
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Nucleus
Involvement in disease
Ovarian dysgenesis 8 (ODG8):
A form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads.
PTM
Phosphorylation at Ser-87 and Ser-105 recruits NCOA1.
More Infomation

Dalal, H., Dahlgren, M., Gladchuk, S., Brueffer, C., Gruvberger-Saal, S. K., & Saal, L. H. (2022). Clinical associations of ESR2 (estrogen receptor beta) expression across thousands of primary breast tumors. Scientific reports, 12(1), 1-12.

He, J., Yan, J. J., Zha, X., Ding, X. J., Zhang, Y. L., Lu, Z., & Xu, X. H. (2022). Sexually dimorphic effects of estrogen receptor 2 deletion in the dorsal raphe nucleus on emotional behaviors. Journal of Neuroendocrinology, e13195.

Asiamah, C. A., Liu, Y., Ye, R., Pan, Y., Lu, L. L., Zou, K., ... & Su, Y. (2022). Polymorphism analysis and expression profile of the estrogen receptor 2 gene in Leizhou black duck. Poultry Science, 101(3), 101630.

Gregorio, K. C. R., Laurindo, C. P., & Machado, U. F. (2021). Estrogen and glycemic homeostasis: the fundamental role of nuclear estrogen receptors ESR1/ESR2 in glucose transporter GLUT4 regulation. Cells, 10(1), 99.

Ulhaq, Z. S., & Garcia, C. P. (2021). Estrogen receptor beta (ESR2) gene polymorphism and susceptibility to dementia. Acta Neurologica Belgica, 121(5), 1281-1293.

Chmielewska, M., Janusz, P., Andrusiewicz, M., Kotwicki, T., & Kotwicka, M. (2020). Methylation of estrogen receptor 2 (ESR2) in deep paravertebral muscles and its association with idiopathic scoliosis. Scientific reports, 10(1), 1-14.

Bahia, W., Soltani, I., Haddad, A., Soua, A., Radhouani, A., Mahdhi, A., & Ferchichi, S. (2020). Association of genetic variants in Estrogen receptor (ESR) 1 and ESR2 with susceptibility to recurrent pregnancy loss in Tunisian women: A case control study. Gene, 736, 144406.

Lang-Muritano, M., Sproll, P., Wyss, S., Kolly, A., Hürlimann, R., Konrad, D., & Biason-Lauber, A. (2018). Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor β (ESR2). The Journal of Clinical Endocrinology & Metabolism, 103(10), 3748-3756.

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For research use only. Not intended for any clinical use.

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