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ERG

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]
Full Name
ERG, ETS Transcription Factor
Research Area
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
Biological Process
Cell differentiation Source: GO_Central
Multicellular organism development Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Protein phosphorylation Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm; Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Involvement in disease
Ewing sarcoma (ES):
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS (PubMed:8187069). Translocation t(X;21)(q25-26;q22) with ELF4 (PubMed:16303180).

Anti-ERG antibodies

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Target: ERG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C6
Application*: IP, WB, M
Target: ERG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: CBFYE-1189
Application*: WB, IP, IF, P, E
Target: ERG
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1188
Application*: WB, IH, IF
Target: ERG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-1187
Application*: WB, IH, IF
Target: ERG
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBFYE-1186
Application*: WB, IF
Target: ERG
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Dog
Clone: CBFYE-1185
Application*: WB, IH, IF
Target: ERG
Host: Rabbit
Specificity: Human, Mouse, Rat, Hamster, Pig, Guinea pig, Horse
Clone: CBFYE-0255
Application*: WB, IP, P, IF, F
Target: ERG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP722
Application*: ICC, IF, IHC, WB
Target: ERG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP721
Application*: FC, ICC, IF, IHC, WB
Target: ERG
Host: Mouse
Specificity: Human
Clone: IHC569
Application*: IH
Target: ERG
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Pig, Guinea pig, Horse
Clone: A7L1G
Application*: WB, IP, P, IF (IC), F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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