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Mouse Anti-ERG Recombinant Antibody (IHC569) (CBMAB-MA084-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
IHC569
Application
IHC (1:100 - 1:200)

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Tris buffer pH 7.3 - 7.7, 1% BSA, < 0.1% Sodium Azide
Storage
Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

Target

Full Name
ERG, ETS Transcription Factor
Introduction
ERG is a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia.
Entrez Gene ID
2078
UniProt ID
P11308
Alternative Names
ERG, ETS Transcription Factor; Transcriptional Regulator ERG (Transforming Protein ERG); V-Ets Avian Erythroblastosis Virus E26 Oncogene Related; V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog; V-Ets Erythroblastosis Virus E26 Oncogene Like; Erythroblast Transformation-Specific Transcription Factor ERG Variant 10; V-Ets Erythroblastosis Virus E26 Oncogene Homolog; TMPRSS2-ERG Prostate Cancer Specific;
Research Area
Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
Biological Process
Cell differentiation Source: GO_Central
Multicellular organism development Source: ProtInc
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Protein phosphorylation Source: ProtInc
Regulation of transcription by RNA polymerase II Source: GO_Central
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm; Nucleus. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Involvement in disease
Ewing sarcoma (ES):
The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS (PubMed:8187069). Translocation t(X;21)(q25-26;q22) with ELF4 (PubMed:16303180).
More Infomation

Gomez-Salinero, J. M., Itkin, T., Houghton, S., Badwe, C., Lin, Y., Kalna, V., ... & Rafii, S. (2022). Cooperative ETS transcription factors enforce adult endothelial cell fate and cardiovascular homeostasis. Nature Cardiovascular Research, 1-18.

Khosh Kish, E., Choudhry, M., Gamallat, Y., Buharideen, S. M., & Bismar, T. A. (2022). The Expression of Proto-Oncogene ETS-Related Gene (ERG) Plays a Central Role in the Oncogenic Mechanism Involved in the Development and Progression of Prostate Cancer. International Journal of Molecular Sciences, 23(9), 4772.

Masamoto, Y., Chiba, A., Takezaki, T., Hino, T., Hayashida, H., Mizuno, H., ... & Kurokawa, M. (2021). EVI1-Positive AML Cells Show Distinct Features and High Dependency on ETS Transcription Factor ERG. Blood, 138, 784.

Saulnier, O., Guedri-Idjouadiene, K., Aynaud, M. M., Chakraborty, A., Bruyr, J., Pineau, J., ... & Dequiedt, F. (2021). ERG transcription factors have a splicing regulatory function involving RBFOX2 that is altered in the EWS-FLI1 oncogenic fusion. Nucleic acids research, 49(9), 5038-5056.

Wasmuth, E. V., Hoover, E. A., Antar, A., Klinge, S., Chen, Y., & Sawyers, C. L. (2020). Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG. Proceedings of the National Academy of Sciences, 117(15), 8584-8592.

Hsing, M., Wang, Y., Rennie, P. S., Cox, M. E., & Cherkasov, A. (2020). ETS transcription factors as emerging drug targets in cancer. Medicinal Research Reviews, 40(1), 413-430.

Kalna, V., Yang, Y., Peghaire, C. R., Frudd, K., Hannah, R., Shah, A. V., ... & Birdsey, G. M. (2019). The transcription factor ERG regulates super-enhancers associated with an endothelial-specific gene expression program. Circulation research, 124(9), 1337-1349.

Nicholas, T. R., Strittmatter, B. G., & Hollenhorst, P. C. (2019). Oncogenic ETS factors in prostate cancer. Prostate Cancer, 409-436.

Sandoval, G. J., Pulice, J. L., Pakula, H., Schenone, M., Takeda, D. Y., Pop, M., ... & Kadoch, C. (2018). Binding of TMPRSS2-ERG to BAF chromatin remodeling complexes mediates prostate oncogenesis. Molecular cell, 71(4), 554-566.

Xu, Z., Wang, Y., Xiao, Z. G., Zou, C., Zhang, X., Wang, Z., ... & Chan, F. L. (2018). Nuclear receptor ERRα and transcription factor ERG form a reciprocal loop in the regulation of TMPRSS2: ERG fusion gene in prostate cancer. Oncogene, 37(48), 6259-6274.

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For research use only. Not intended for any clinical use.

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