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ENTPD1

The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene.
Full Name
Ectonucleoside Triphosphate Diphosphohydrolase 1
Research Area
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Biological Process
Blood coagulation Source: ProtInc
Cell adhesion Source: ProtInc
Nucleoside diphosphate catabolic process Source: GO_Central
Cellular Location
Membrane
Involvement in disease
Spastic paraplegia 64, autosomal recessive (SPG64):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Topology
Cytoplasmic: 1-16
Helical: 17-37
Extracellular: 38-478
Helical: 479-499
Cytoplasmic: 500-510
PTM
The N-terminus is blocked.
Palmitoylated in the N-terminal part.

Anti-ENTPD1 antibodies

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Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CF149
Application*: ELISA, WB, IF
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1348
Application*: WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0624
Application*: F, IP, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: CBYY-C0377
Application*: F, WB, E
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 990
Application*: ELISA, IF, WB
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Human
Clone: R22
Application*: F
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MZ18-23C8
Application*: F
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: TU66
Application*: F
Target: ENTPD1
Host: Rabbit
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 9H84
Application*: FC
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H171
Application*: FC, IH, IP, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1279
Application*: FC
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBWJC-3621
Application*: WB, P
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Mouse
Clone: CBWJC-3619
Application*: WB
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-3618
Application*: E, F, IP, WB
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBWJC-3616
Application*: F
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-3615
Application*: WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2121
Application*: F, C
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2120
Application*: F, IP, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2119
Application*: WB, F, IC, IP, MC
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1
Application*: F
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBXC-1513
Application*: F, IP, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1223
Application*: WB
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG
Specificity: Mouse
Clone: Duha59
Application*: F
Target: ENTPD1
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0926
Application*: F
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1222
Application*: F
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AC2.5
Application*: F, IF
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AC2
Application*: WB, F
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human, Mouse, Rat
Clone: CBXC-2451
Application*: WB, IH, P
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C1349
Application*: F
Target: ENTPD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-2610
Application*: E
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-2609
Application*: P, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-2608
Application*: WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human
Clone: CBFYC-0337
Application*: P, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Mouse
Clone: 5F2
Application*: C, WB, E
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C2
Application*: WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 22A9
Application*: P
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1G8
Application*: WB
Target: ENTPD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: 004
Application*: E
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 498403
Application*: F, MC
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: 495826
Application*: WB, F, P, C
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 24DMS1
Application*: C, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b, λ
Specificity: Human, Mouse, Rat
Clone: 17B5F11
Application*: WB, IH, P
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0906
Application*: WB, IH
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0221
Application*: WB, P
Target: ENTPD1
Host: Rat
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYE-0220
Application*: E, F, IP, WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: ABM41E2
Application*: WB
Target: ENTPD1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2D2H6
Application*: E, WB, IF, F
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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