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EIF4EBP1

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Full Name
Eukaryotic Translation Initiation Factor 4E Binding Protein 1
Research Area
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
Biological Process
Cellular response to hypoxia Source: Ensembl
G1/S transition of mitotic cell cycle Source: UniProtKB
Lung development Source: Ensembl
Negative regulation of protein-containing complex assembly Source: Ensembl
Negative regulation of translational initiation Source: UniProtKB
Positive regulation of mitotic cell cycle Source: UniProtKB
Response to amino acid starvation Source: Ensembl
Response to ethanol Source: Ensembl
Response to ischemia Source: Ensembl
TOR signaling Source: UniProtKB
Cellular Location
Cytosol; Postsynaptic cytosol; Nucleus; Cytoplasm; Glutamatergic synapse; Protein-containing complex
PTM
Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-37, Thr-46, Ser-65 and Thr-70, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E.
Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-37, Thr-46, Ser-65 and Thr-70) or associated with eIF4E.

Anti-EIF4EBP1 antibodies

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Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CAP684
Application*: IF, IHC, IP, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 133
Application*: ELISA, IF, IHC, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CF148
Application*: ELISA, WB, IF
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1F7
Application*: WB, E
Target: EIF4EBP1
Host: Canine
Specificity: Human
Clone: CBCNC-591
Application*: E
Target: EIF4EBP1
Host: Rabbit
Specificity: Human, Monkey
Clone: D7F6I
Application*: WB, IP
Target: EIF4EBP1
Host: Mouse
Specificity: Human, Mouse, Rat
Clone: D-10
Application*: WB, IP, IF, P, E
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 9E12D9
Application*: WB, E
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Drosophila, Human, Monkey, Mouse, Rat
Clone: 9B142
Application*: WB, IH, FC, IF
Target: EIF4EBP1
Host: Rabbit
Specificity: Human, Mouse, Rat, Monkey
Clone: 87D12
Application*: WB, IF, FC
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 7H1
Application*: E, FC, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5F3G9
Application*: WB, E, IF, IF
Target: EIF4EBP1
Host: Rabbit
Specificity: Human, Monkey, Chicken
Clone: 174A9
Application*: WB, IP
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B3
Application*: E, IH
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B2
Application*: E, IH, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B1
Application*: E, WB
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10F619
Application*: IH, WB
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 58
Application*: WB, E
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 46
Application*: IF
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: M34-273
Application*: FC
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: M31-16
Application*: FC
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYE-0725
Application*: E, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-0724
Application*: E, IF
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYE-0723
Application*: E, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYE-0186
Application*: IF, IH, IP, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat, Human
Clone: 554R16
Application*: WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F3-H2
Application*: E, IF, PL, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 319CT22.8.2
Application*: E, WB
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: E.992.6
Application*: F, IC, IF, P, WB
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBLQE-001
Application*: WB, P, IF, F
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: 53H11
Application*: WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B6G10
Application*: WB, IH
Target: EIF4EBP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Common fruit fly
Clone: 236B4
Application*: F, WB
Target: EIF4EBP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 11G12C11
Application*: E, IH, P, WB
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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