DYNC1I1

DYNC1I1 (Dynein Cytoplasmic 1 Intermediate Chain 1) is a Protein Coding gene. Diseases associated with DYNC1I1 include Paranoid Personality Disorder and Split-Hand/Foot Malformation 2. Among its related pathways are COPI-independent Golgi-to-ER retrograde traffic and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include microtubule binding and motor activity. An important paralog of this gene is DYNC1I2.

dynein cytoplasmic 1 intermediate chain 1

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Microtubule-based movement Source: GO_Central
Transport along microtubule Source: GO_Central
Vesicle transport along microtubule Source: UniProtKB

Cytoplasm; Spindle pole; Kinetochore