DDAH1

This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. [provided by RefSeq, Jul 2008]

Dimethylarginine Dimethylaminohydrolase 1

Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.

Arginine catabolic process Source: BHF-UCL
Arginine metabolic process Source: GO_Central
Citrulline metabolic process Source: UniProtKB
Negative regulation of cell population proliferation Source: BHF-UCL
Negative regulation of cellular response to hypoxia Source: BHF-UCL
Negative regulation of vascular permeability Source: BHF-UCL
Nitric oxide mediated signal transduction Source: ProtInc
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of nitric oxide biosynthetic process Source: BHF-UCL
Regulation of nitric-oxide synthase activity Source: Reactome
Regulation of systemic arterial blood pressure Source: BHF-UCL

Cytosol; Extracellular exosome