DCTD

The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for thymidylate synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DCMP Deaminase

Supplies the nucleotide substrate for thymidylate synthetase.

dTMP biosynthetic process Source: GO_Central
dUMP biosynthetic process Source: GO_Central
Nucleobase-containing small molecule interconversion Source: Reactome
Pyrimidine nucleotide metabolic process Source: ProtInc

Cytosol