DCN

This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. [provided by RefSeq, Nov 2015]

Decorin

May affect the rate of fibrils formation.

Aging Source: Ensembl
Animal organ morphogenesis Source: ProtInc
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Kidney development Source: Ensembl
Negative regulation of angiogenesis Source: MGI
Negative regulation of endothelial cell migration Source: MGI
Negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Placenta development Source: Ensembl
Positive regulation of autophagy Source: CACAO
Positive regulation of macroautophagy Source: MGI
Positive regulation of mitochondrial depolarization Source: MGI
Positive regulation of mitochondrial fission Source: MGI
Positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Wound healing Source: Ensembl

Extracellular matrix

Corneal dystrophy, congenital stromal (CSCD):
A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.

The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.