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Rat Anti-DCN Recombinant Antibody (D0379) (CBMAB-D0379-YC)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
D0379
Antibody Isotype
IgG2
Application
ELISA, WB

Basic Information

Immunogen
Mouse recombinant protein Decorin.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:1,000-1:2,000
WB1:500-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
0.2 mg/ml

Target

Full Name
Decorin
Entrez Gene ID
13179
UniProt ID
P28654
Function
May affect the rate of fibrils formation.
Biological Process
Aging Source: Ensembl
Animal organ morphogenesis Source: ProtInc
Chondroitin sulfate biosynthetic process Source: Reactome
Chondroitin sulfate catabolic process Source: Reactome
Dermatan sulfate biosynthetic process Source: Reactome
Extracellular matrix organization Source: Reactome
Kidney development Source: Ensembl
Negative regulation of angiogenesis Source: MGI
Negative regulation of endothelial cell migration Source: MGI
Negative regulation of vascular endothelial growth factor signaling pathway Source: MGI
Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan Source: Ensembl
Placenta development Source: Ensembl
Positive regulation of autophagy Source: CACAO
Positive regulation of macroautophagy Source: MGI
Positive regulation of mitochondrial depolarization Source: MGI
Positive regulation of mitochondrial fission Source: MGI
Positive regulation of phosphatidylinositol 3-kinase signaling Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Response to lipopolysaccharide Source: Ensembl
Response to mechanical stimulus Source: Ensembl
Skeletal muscle tissue development Source: Ensembl
Wound healing Source: Ensembl
Cellular Location
Extracellular matrix
Involvement in disease
Corneal dystrophy, congenital stromal (CSCD):
A corneal dystrophy characterized by congenital corneal opacification consisting of a large number of flakes and spots throughout all layers of the stroma. It results in progressive, painless visual loss. Corneal erosions and photophobia are absent.
PTM
The attached glycosaminoglycan chain can be either chondroitin sulfate or dermatan sulfate depending upon the tissue of origin.
More Infomation

Balne, P. K., Gupta, S., Zhang, J., Bristow, D., Faubion, M., Heil, S. D., ... & Mohan, R. R. (2021). The functional role of decorin in corneal neovascularization in vivo. Experimental Eye Research, 207, 108610.

Shibata, S., Shibata, N., Ohtsuka, S., Yoshitomi, Y., Kiyokawa, E., Yonekura, H., ... & Kubo, E. (2021). Role of Decorin in Posterior Capsule Opacification and Eye Lens Development. Cells, 10(4), 863.

Han, B., Li, Q., Wang, C., Chandrasekaran, P., Zhou, Y., Qin, L., ... & Han, L. (2021). Differentiated activities of decorin and biglycan in the progression of post-traumatic osteoarthritis. Osteoarthritis and Cartilage, 29(8), 1181-1192.

Halari, C. D., Nandi, P., Jeyarajah, M. J., Renaud, S. J., & Lala, P. K. (2020). Decorin production by the human decidua: role in decidual cell maturation. Molecular Human Reproduction, 26(10), 784-796.

Reszegi, A., Horváth, Z., Fehér, H., Wichmann, B., Tátrai, P., Kovalszky, I., & Baghy, K. (2020). Protective role of decorin in primary hepatocellular carcinoma. Frontiers in oncology, 10, 645.

Daquinag, A. C., Gao, Z., Fussell, C., Sun, K., & Kolonin, M. G. (2020). Glycosaminoglycan modification of Decorin depends on MMP14 activity and regulates collagen assembly. Cells, 9(12), 2646.

Sainio, A. O., & Järveläinen, H. T. (2019). Decorin‐mediated oncosuppression–a potential future adjuvant therapy for human epithelial cancers. British Journal of Pharmacology, 176(1), 5-15.

Vu, T. T., Marquez, J., Le, L. T., Nguyen, A. T. T., Kim, H. K., & Han, J. (2018). The role of decorin in cardiovascular diseases: more than just a decoration. Free Radical Research, 52(11-12), 1210-1219.

Zhang, W., Ge, Y., Cheng, Q., Zhang, Q., Fang, L., & Zheng, J. (2018). Decorin is a pivotal effector in the extracellular matrix and tumour microenvironment. Oncotarget, 9(4), 5480.

Shen, Y., Russo, V., Zeglinski, M. R., Sellers, S. L., Wu, Z., Oram, C., ... & Granville, D. J. (2017). Recombinant decorin fusion protein attenuates murine abdominal aortic aneurysm formation and rupture. Scientific reports, 7(1), 1-9.

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For research use only. Not intended for any clinical use.

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